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ProteomicsGenome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Hypomethylating agents (HMAs) are frontline therapies effective at altering the natural course of Myelodysplastic Neoplasms (MDS). However, acquired resistance and treatment failure are hallmarks of HMA therapy. Developing effective and rational HMA-focused combinatorial therapies is challenging as...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD050539 | Pride
Myelodysplastic neoplasms Proteomics Genome-wide crispr-cas9 screen Sumo 
ProteomicsHuman Blood Serum LC-MS/MS - Serological epithelial component proteins identify intestinal complications in Crohn's Disease
Quantitative proteome profiling was performed on Inflammatory (ICD), stricturing and fistulizing Crohn's Disease serums using label-free Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
ORGANISM(S): Homo sapiens (Human) 
2017-05-15 | PXD001821 | Pride
Human serum lc-ms/ms 
UnknownVarR controls colonization and virulence in the marine macroalgal pathogen Nautella italica R11.
Not available
S-EPMC4602140 | biostudies-literature
UnknownApplication of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System.
Not available
S-EPMC5071856 | biostudies-literature
MetabolomicsMetabolic Dynamics in Escherichia coli-Based Cell-Free Systems
The field of metabolic engineering has yielded remarkable accomplishments in using cells to produce valuable molecules, and cell-free expression (CFE) systems have the potential to push the field even further. However, CFE systems still face some outstanding challenges, including endogenous metaboli...
2023-02-22 | MTBLS2630 | MetaboLights
UnknownTOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.
Not available
S-EPMC11358519 | biostudies-literature
ProteomicsSpatial proteomics defines the content of trafficking vesicles captured by golgin tethers
Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD018110 | Pride
Lopit-dc Organell protein relocalization Golgin Hela 
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
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