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TranscriptomicsSwitching on antibiotic resistance in Staphylococcus aureus M-bM-^@M-^S Contribution of WalK and VraS histidine kinases in the development of vancomycin and daptomycin resistance
Staphylococcus aureus is a notorious bacterial pathogen that causes a broad range of human diseases, and isolates that are resistant to several antibiotic classes including last resort antibiotics like vancomycin and daptomycin complicate the situation. We characterized S. aureus VC40, a strain that...
ORGANISM(S): Staphylococcus aureus subsp. aureus Mu50 
2014-08-18 | E-GEOD-46887 | biostudies-arrayexpress
ProteomicsComparative glycoproteomics of embryonic stem cells identifies new players in ricin toxicity
Rapid advances in the fields of DNA-, RNA-, polypeptide-sequencing and metabolomics have markedly enhanced our understanding of fundamental biological processes. In contrast to other post-translational modifications (PTMs), the most abundant PTM, glycosylation, remains largely unexplored at the prot...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-25 | PXD005804 | Pride
Glycosylation Glycoproteomics Stem cells 
TranscriptomicsMetabolic modeling of antibiotic and cytotoxic effects of the isoquinoline IQ-238 in S. aureus, S. epidermidis and human cells
Isoquinolines (IQs) are natural substances with antibiotic potential. IQ-238 is a synthetic analog of the novel-type N,C-coupled naphtylisoquinoline (NIQ) alkaloid ancisheynine. Gene expression data, cytotoxicity measurements and metabolic modelling is combined to assess the effects of the N,C-coup...
ORGANISM(S): Staphylococcus aureus 
2015-04-30 | E-GEOD-33832 | biostudies-arrayexpress
ProteomicsSNW1 is required for sister chromatid cohesion
Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here we show that the spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in hum...
ORGANISM(S): Homo sapiens (Human) 
2016-06-29 | PXD001249 | Pride
Pre-mrna splicing Snw1 Mitosis Cell cycle Sister chromatid cohesion 
ProteomicsCtenophore organic matter degradation experiment
Microcosm experiment on degradation of organic matter from M. Leidyi by marine bacteria
ORGANISM(S): Pseudoalteromonas phenolica 
2024-01-14 | PXD043478 | Pride
Ctenophore Lc-msms Bacteria 
ProteomicsPhosphoproteomics of MuSK Signaling
The development of the neuromuscular synapse depends on signaling processes which involve protein phosphorylation as a crucial regulatory event. The receptor tyrosine kinase MuSK is the key signaling molecule at the neuromuscular synapse whose activity is required for the formation of a mature and f...
ORGANISM(S): Mus musculus (Mouse) 
2014-06-05 | PXD000558 | Pride
Phospho Musk Mouse Neuromuscular synapse 
ProteomicsPhosphoproteomics of MuSK Signaling
The development of the neuromuscular synapse depends on signaling processes which involve protein phosphorylation as a crucial regulatory event. The receptor tyrosine kinase MuSK is the key signaling molecule at the neuromuscular synapse whose activity is required for the formation of a mature and f...
ORGANISM(S): Mus musculus (Mouse) 
2014-06-05 | PXD000878 | Pride
Musk Time course Phosphoproteomics Itraq Muscle 
UnknownDiscrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology.
Not available
S-EPMC1770358 | biostudies-literature
GenomicsMolecular Genetic Studies of Developmental Brain Disorders

Study 1
2R01-NS050375 (PI: DOBYNS, William B.)
The genetic basis of mid-hindbrain malformations
Our general goal for this project is to advance our understanding of human developmental disorders that involve the brainstem and cerebellum - brain structures derived from the embryoni...

phs000455.v1.p1 | EGA
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