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MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (L-Alanine-treated macrophage metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7986 | MetaboLights
TranscriptomicsTranscription profiling by array of rat macrophages from WKY/NCrl and LEW/Crl strains to determine susceptibility to glomerulonephritis
The Wistar-Kyoto (WKY) rat shows marked susceptibility to crescentic glomerulonephritis, while Lewis rats are resistant. Glomerular injury and crescent formation are macrophage-dependent. The aim of this study is to use gene expression profiling to identify genetic factors that determine macrophage ...
ORGANISM(S): Rattus norvegicus 
2011-03-17 | E-MEXP-2624 | biostudies-arrayexpress
ProteomicsInvestigating macrophage multinucleation by LC-MS/MS
Macrophage multinucleation (MM) is essential for various biological processes such as osteoclast-mediated bone resorption and multinucleated giant cell-associated inflammatory reactions. Here we study the molecular pathways underlying multinucleation in the rat through an integrative approach combin...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-06 | PXD001269 | Pride
Rat Protein Wky Macrophage 
TranscriptomicsRole of JunD in macrophage activation under LPS stimulation
To investigate the effects of the differences seen in the JUND binding patterns between LEW, WKY and WKY.LCrgn2 bone marrow derived macrophages (BMDMs), we have 1) analysed gene expression changes over a time course (4 time points: 0,2,4 and 8 hrs) of stimulation with lipopolysaccharide (LPS) using ...
ORGANISM(S): Rattus norvegicus 
2013-04-01 | E-MEXP-3469 | biostudies-arrayexpress
TranscriptomicsExpression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain
Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are ...
ORGANISM(S): Rattus norvegicus 
2011-06-11 | E-GEOD-29885 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in rat mesenteric lymph nodes upon supplementation with conjugated linoleic acid during gestation and suckling
A summary of the work associated to these microarrays is the following: Diet plays a role in the development of the immune system, and polyunsaturated fatty acids can modulate the expression of a variety of genes. Human milk contains conjugated linoleic acid (CLA), a fatty acid that seems to contri...
ORGANISM(S): Rattus norvegicus 
2011-07-21 | E-GEOD-23004 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary rat macrophages cultured on substrates of defined stiffness
Cells interact with their mechanical environment and respond in consequence. Mechanical cues can have a wide range of influences on cell behaviour, ranging from guidance of differentiation and cell fate to immune activation. The impact of substrate stiffness on primary macrophages - a key player in ...
ORGANISM(S): Rattus norvegicus 
2023-04-15 | E-MTAB-7900 | biostudies-arrayexpress
ProteomicsCD68+ region of rat scar tissue by AutoSTOMP
To test the ability of the Automated Spatially Targeted Optical Micro Proteomics (AutoSTOMP) protocol to selectively biotinylate structures of interest within tissue sections we first examined a rat myocardial infarction model. In this model, trauma caused by ligation and infiltrating immune cells c...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-08-10 | PXD026818 | Pride
Macrophage Rat cardiac scar Autostomp 
TranscriptomicsMultinucleated Tartrate Resistant Acid Phosphatase Positive Cells with Macrophage and Osteoclast Phenotypes in Bone
Prothrombin (PT) and osteopontin (OPN) promotes adhesion of different TRAP-positive multinucleated cells isolated from rat long bone (Hu et al. Exp Cell Res. 2008; 314: 638-50). The PT-adhering cell could represent either an immature precursor to the OPN-adherent osteoclast or constitute a distinct...
ORGANISM(S): Rattus norvegicus 
2010-12-31 | E-GEOD-19950 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat CNS mixed glial cultures treated with cytokines
To examine changes in gene expression that might occur in CNS glial cells in response to the secreted products of immune cells, we used gene array analysis to assess the early effects of different cytokine mixtures on rat mixed CNS glia in culture. We compared effects at 6 hours of cytokines typical...
ORGANISM(S): Rattus norvegicus 
2008-11-15 | E-GEOD-9659 | biostudies-arrayexpress
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