Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of unesterified cholesterol in the late endosomal/lysosomal compartments. Mutations in the NPC1 protein are implicated in 95% of patients with NPC disease. The most prevalent mutation is the mis...
The recent identification of catalytically active peptidylglycine -amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic common ancestor (LECA). Homologs of prototypical neurop...
Data from ProteomeXchange, PXD ID: PXD001938. Experiment: WTvsI1061T_TMT_inj01, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Apr 14 . From the Abstract: {{i}} In our study, an isobaric labeling based quantitative analysis of proteome of NPC1I1061T (sic) primary fibroblasts w...
Niemann-Pick type C (NPC) disease is an inherited, progressive neurodegenerative disorder principally caused by mutations in the NPC1 gene. NPC disease is characterized by the accumulation of unesterified cholesterol in the late endosomes (LE) and lysosomes (LE) (LE/LY). Vorinostat, a histone deacet...
