Red blood cells (RBC) play a critical role in oxygen transport, and are the focus of important human diseases including malaria and the haemoglobinopathies. Although previous studies aimed at classifying the RBC proteome have examined whole or membrane-enriched fractions from RBC, none have used spe...
Duffy antigen receptor for chemokines (DARC) is the primary red blood cell (RBC) receptor for invasion of human RBCs by Plasmodium vivax and Plasmodium knowlesi merozoites. By contrast, Plasmodium falciparum parasites, which are the dominant cause of malaria in West and Central Africa, use multiple ...
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane then seals and pinches off behind the parasite through an unknown mechanism, enclosing it within the RBC. During invasion, several merozoite surface...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7)
The high prevalence of sickle cell disease in some human populations likely results from the protection afforded against severe Plasmodium falciparum malaria and death by heterozygous carriage of HbS. P. falciparum remodels the erythrocyte membrane and skeleton, displaying parasite proteins at the e...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7)
Data from ProteomeXchange, PXD ID: PXD000434. Experiment: 111213_RBC5_MG, file: 111213_RBC5_MG_Fr15_17.mzml. Published as part of J Proteome Res. 2014 Apr 4;13(4):2028-44 . From the Abstract: {{i}} Enucleated and largely void of internal membranes and organelles, erythrocytes are simple yet proteom...
Certain serum proteins, including CRP and D-dimer, have prognostic value in patients with SARS-CoV-2 infection. Nonetheless, these factors are non-specific, and provide limited mechanistic insight into the peripheral blood mononuclear cell (PBMC) populations which drive the pathogenesis of severe CO...
