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TranscriptomicsTranscriptional profiling of Control vs. Pinealectomised Syrian hamster testes
Transcriptional profiling of male Syrian hamster testes, comparing control animals with those that have had a pinealectomy. Keywords: transcriptional profiling Two-condition experiment, Control vs pinealectomised animals
ORGANISM(S): Mesocricetus auratus 
2010-05-26 | E-GEOD-10078 | biostudies-arrayexpress
ProteomicsTwenty-four hour rhythms in the absence of the clock gene Bmal1
Circadian (~24 hour) clocks exist in almost all types of living organism and play a fundamental role in regulating daily physiological and behavioural processes. The transcription factor BMAL1 (ARNTL) is thought to be one of the principal drivers of the molecular clock in mammals since its deletion ...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD009243 | Pride
Bmal1  circadian rhythms  kinase network  non-transcriptional oscillators  rhythmic proteome and phosphoproteome 
ProteomicsSingle-cell transcriptomics and cell-specific proteomics reveals new molecular regulators of sleep
Every day, we sleep for a third of the day. Sleep is important for cognition, brain waste clearance, metabolism, and immune responses. Homeostatic regulation of sleep is maintained by progressively rising sleep need during wakefulness, which then dissipates during sleep. The molecular mechanisms gov...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD018334 | Pride
Phosphoproteomics Differential proteomics Tandem mass tag Sleep deprivation Neuron Strocyte Single-cell rna sequencing Brainstem Hypothalamus Cortex 
GenomicsCircadian cycling of genome-wide histone methylation
Daily (circadian) clocks are essential for regulating and coordinating physiology in mammals. Modulation of local chromatin structure has been shown for only a small number of genes, principally thought to be directly modulated by Clock-mediated histone acetylation. Here we show that genome-wide cha...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-23550 | biostudies-arrayexpress
ProteomicsPhenotypic Proteomic Profiling Reveals Convergent Kinase Targets for Circadian Clock Modulators
Determining the mechanisms of action of drug molecules that modulate circadian rhythms is critical to develop novel compounds to treat clock disorders. Here we employed Phenotypic Proteomic Profiling (PPP) integrating multipronged proteomics approaches including global proteome, phosphoproteome, kin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD014186 | Pride
Circadian rhythms  circadian period altering compounds  kinase  phenotypic proteome profiling  phosphoproteome  proteomics  thermal proteome profiling 
ProteomicsNon-canonical circadian oscillations in Drosophila S2 cells
Circadian rhythms are cell-autonomous biological oscillations with a period of about 24 hours. Current models propose that transcriptional feedback loops are the principal mechanism for the generation of circadian oscillations. In these models, Drosophila S2 cells are generally regarded as ‘non-rhyt...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-07-31 | PXD007669 | Pride
Tmt Lc-ms Circadian Clock 
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