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ProteomicsIn-Depth Proteomics Reveals Selective EV Protein Sorting and Pathway Perturbation in AML upon Synergistic FLT3 and Hedgehog Pathway Inhibition
Acute myeloid leukemia (AML) is an aggressive cancer mainly affecting bone marrow and blood with a high relapse incidence and mortality rate. Approximately one third of AML patients carry an fms-like tyrosine kinase 3 (FLT3) mutation, which is often associated with GLI expression and Hedgehog signal...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD061404 | Pride
Hpi-1 Proteomics Erbb signaling Evs Crenolanib Ribosomal proteins Aml 
ProteomicsA Generic HPLC Method for Absolute Quantification of Oxidation in Monoclonal Antibodies and Fc-Fusion Proteins Using UV and MS Detection
Absolute quantification of methionine oxidation in the Fc domain of biopharmaceuticals. Wedeveloped a middle-down approach employing the cysteine protease IdeS under reducing conditions to obtain three mAb subunits of approximately 25 kDa: Fc/2, Fd’ and LC. These subunits were separated by ion-pair ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD006873 | Pride
Ion-pair reversed-phase Q exactive Ides 
ProteomicsDilute-and-Shoot Analysis of Therapeutic Monoclonal Antibody Variants in Fermentation Broth: A Method Capability Study
Monoclonal antibodies (mAbs) are widely applied as highly specific and efficient thera-peutic agents for various diseases, including cancer, inflammatory and autoimmune diseases. As protein production in cellular systems inherently generates a multitude of molecular variants, manufacturing of mAbs r...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011017 | Pride
Glycation Monoclonal antibodies Process analytical technology Electrospray ionization mass spectrometry Pat Glycosylation Biosimilar Mam Multiple attribute monitoring Antibody subunits Structural analysis Fermentation Process monitoring High-performance liquid chromatography 
ProteomicsDeceptive Ceropegia sandersonii uses an arabinogalactan for trapping its fly pollinators
Many plant species have evolved surfaces designed to reduce insect attachment. Among such plants are deceptive trap flowers of Ceropegia. Their gliding zones consist of epidermal cells each topped by a papilla secreting a single small liquid droplet on its tip. So far, the molecular and physical mec...
ORGANISM(S): Ceropegia sandersonii 
2025-04-11 | PXD062347 | Pride
Nmr spectroscopy Anti-adhesive surface Peptide mapping Mass spectrometry Agp Polysaccharide Ceropegia sandersonii Monosaccharide composition Fly-trapping flower 
ProteomicsHelicobacter pylori induces a novel form of innate immune memory via accumulation of NF-кB proteins
Helicobacter pylori is a widespread Gram-negative pathogen involved in a variety of gastrointestinal diseases, including gastritis, ulceration, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. Immune responses aimed at eradication of H. pylori often prove futile, and paradoxical...
ORGANISM(S): Homo sapiens (Human) 
2023-11-10 | PXD045072 | Pride
Tmt labelled 
ProteomicsADP-heptose attenuates H. pylori-induced type I IFN signaling in DCs and impairs subsequent T cell responses
Helicobacter pylori (H. pylori) colonizes the gastric mucosa of approximately 50% of the world’s population. While it is well established that H. pylori is a major cause of gastric cancer, it has only recently been reported that H. pylori can also have adverse effects on immunological processes, in...
ORGANISM(S): Homo sapiens (Human) 
2024-09-13 | PXD046603 | Pride
Shotgun proteomics Cd8 Adp heptose Label-free quantification H. pylori 
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