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ProteomicsRegulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3
Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we describe a novel role for PARP1 and PARP2 in regulating Rad52-dependent replication fork repair to maintain cell viability when HR is dys...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035661 | Pride
Proteomics Dna repair Adpr Parps Lumos Adp-ribosyltransferases Adp-ribosylation Af1521 Dna replication 
ProteomicsTemporal and site-specific ADP-ribosylation dynamics upon different genotoxic stresses
The DNA damage response revolves around transmission of information via post-translational modifications, including reversible protein ADP-ribosylation. Here, we applied a mass spectrometry-based Af1521 enrichment technology for the identification and quantification of ADP-ribosylation sites as a fu...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028902 | Pride
Proteomics Mass spectrometry Parp Post-translational modification Dna damage Af1521 Adp-ribosylation 
GenomicsInsulin post-transcriptional regulation via PARP12-mediated ADP-ribosylation
Insulin post-transcriptional regulation via PARP12-mediated ADP-ribosylation
PRJNA1238844 | ENA
ProteomicsMapping physiological ADP-ribosylation using Activated Ion Electron Transfer Dissociation (AI-ETD)
ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under physiological conditions, without relying on genetic or chemical perturbation, has been hindered by technical limitations. ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-23 | PXD017417 | Pride
Activated ion electron transfer dissociation Post-translational modification Adpr Ptm Parp Ai-etd Adp-ribosylation 
GenomicsUnrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
PRJNA702803 | ENA
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 1)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD023835 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
TranscriptomicsInsulin post-transcriptional regulation via PARP12-mediated ADP-ribosylation
ADP-ribosylation is a common modification that occurs in proteins and nucleic acids, regulating many cellular processes ranging from DNA repair to inflammatory signaling. ADP-ribosylation plays an important role in cancer biology, infectious diseases, and obesity, but its role in the development of ...
ORGANISM(S): Mus musculus 
2025-03-28 | GSE292484 | GEO
ProteomicsThe regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome (part 2)
Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone P...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-10-11 | PXD027504 | Pride
Parp1 Adpr Hpf1 Arh3 Par Parg Af1521 Mar Adp-ribosylation 
UnknownProteasome regulation by ADP-ribosylation.
Not available
S-EPMC3676968 | biostudies-literature
ProteomicsLack of the mitochondrial NAD transporter SLC25A51 redistributes NAD+ compartmentalization and cellular ADP-ribosylation
Nicotinamide adenine dinucleotide (NAD+) is a vital small molecule with important redox capacity in oxidative phosphorylation (OXPHOS) and a key co-factor in various enzymatic reactions. The recent identification of the mitochondrial NAD+ transporter SLC25A51 provides strong evidence for a direct re...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD031373 | Pride
Sl25a51 Adp-ribosylation Mitochondia 
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