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ProteomicsDynamic proximity based interactome of the transcription factor RELA to identify gene-regulatory networks revealed
Using p65-miniTurbo fusion proteins in HeLa cells, we identified by biotin tagging > 350 RELA interactors from untreated and IL-1a-stimulated cells, including many TFs (47 % of all interactors) and > 50 epigenetic regulators belonging to different classes of chromatin remodeling complexes.
ORGANISM(S): Homo sapiens (Human) 
2024-11-04 | PXD045888 | Pride
Lc-msms Rela Affinity proteomics Turbo id Genetic networks P65 nf-kb Interactome 
UnknownThe proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA.
Not available
S-EPMC11850942 | biostudies-literature
ProteomicsQuantitative assessment of the effects of trypsin digestion methods on immunoprecipitation-mass spectrometry-based protein-protein interaction analysis
Immunoprecipitation-mass spectrometry (IP-MS) has become the method of choice for discovering protein-protein interaction (PPI) under native conditions. The success of the IP-MS depends on the efficiency of trypsin digestion and recovery of the tryptic peptides for MS analysis. Several different pro...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Homo sapiens (Human) 
2017-07-25 | PXD005984 | Pride
Rela interactome Trypsin digestion Protein-protein interaction 
ProteomicsTemporal modulation of the NF-kB network in response to different types of DNA damage HYDROXYUREA C4PR_LIV
Different types of DNA damage can initiate phosphorylation-mediated signalling cascades that result in stimulus specific pro- or anti-apoptotic cellular responses. Amongst its many roles, the NF-κB transcription factor RelA is central to the DNA damage response pathway. Yet, understanding of the co-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019589 | Pride
Dna damage  rela  p65  nf-κb  phosphorylation  mass spectrometry Phosphoproteomics  etoposide  hydroxyurea 
ProteomicsTemporal modulation of the NF-kB network in response to different types of DNA damage ETOPOSIDE C4PR_LIV
Different types of DNA damage can initiate phosphorylation-mediated signalling cascades that result in stimulus specific pro- or anti-apoptotic cellular responses. Amongst its many roles, the NF-κB transcription factor RelA is central to the DNA damage response pathway. Yet, understanding of the co-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019587 | Pride
Dna damage  rela  p65  nf-κb  phosphorylation  mass spectrometry Phosphoproteomics  etoposide  hydroxyurea 
UnknownThe proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-kappaB / RELA
Not available
S-SCDT-10_1038-S44319-024-00339-8 | biostudies-other
ProteomicsQuantitative assessment of the effects of trypsin digestion methods on immunoprecipitation-mass spectrometry-based protein-protein interaction analysis - part2
Immunoprecipitation-mass spectrometry (IP-MS) has become the method of choice for discovering protein-protein interaction (PPI) under native conditions. The success of the IP-MS depends on the efficiency of trypsin digestion and recovery of the tryptic peptides for MS analysis. Several different pro...
ORGANISM(S): Homo sapiens (Human) 
2017-07-26 | PXD006739 | Pride
Protein-protein interaction Trypsin digestion Lc-ms/ms 
UnknownGlobal Interactome Mapping Reveals Pro-tumorigenic Interactions of NF-κB in Breast Cancer.
Not available
S-EPMC10988130 | biostudies-literature
UnknownCo-expression of RelA/p65 and ACTN4 induces apoptosis in non-small lung carcinoma cells.
Not available
S-EPMC5969568 | biostudies-literature
UnknownTemporal modulation of the NF-κB RelA network in response to different types of DNA damage.
Not available
S-EPMC7886319 | biostudies-literature
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