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ProteomicsUSP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG unloading and replisome disassembly are poorly described. Since...
ORGANISM(S): Homo sapiens (Human) 
2025-05-16 | PXD061463 | Pride
Usp37 Cell cycle Ubiquitin Dna replication Replisome 
UnknownCharacterizing replisome disassembly in human cells.
Not available
S-EPMC11269944 | biostudies-literature
ProteomicsImmunoprecipitation of p97 from X.laevis S-phase chromatin
Complex cellular processes are driven by the regulated assembly and disassembly of large multi-protein complexes. In eukaryotic DNA replication, whilst we are beginning to understand the molecular mechanism for assembly of the replication machinery (replisome), we still know little about the regulat...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-10-14 | PXD029705 | Pride
Vcp Replisome disassembly Xenopus laevis P97 Dna replication 
UnknownA conserved mechanism for regulating replisome disassembly in eukaryotes.
Not available
S-EPMC8695382 | biostudies-literature
UnknownThe p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase.
Not available
S-EPMC9358472 | biostudies-literature
UnknownLRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components.
Not available
S-EPMC8160578 | biostudies-literature
UnknownMitotic replisome disassembly depends on TRAIP ubiquitin ligase activity.
Not available
S-EPMC6464043 | biostudies-literature
UnknownTIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans.
Not available
S-EPMC8408604 | biostudies-literature
UnknownTethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase.
Not available
S-EPMC4562905 | biostudies-literature
UnknownSingle-strand DNA breaks cause replisome disassembly.
Not available
S-EPMC7979477 | biostudies-literature
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