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ProteomicsEquine gluteal muscle LC-MSMS: Thoroughbred
Recurrent exertional rhabdomyolysis (RER) develops in 5-10% of Thoroughbred racehorses. High-stress environments, nervous temperament, and diet influence the presentation of RER. RER-susceptibility is associated with alterations in intramuscular Ca2+ regulation with detrimental effects on mitochondr...
ORGANISM(S): Equus caballus (Horse) 
2021-01-07 | PXD020100 | Pride
Rer Muscle Thoroughbred Equine 
UnknownThe Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP.
Not available
S-EPMC6813913 | biostudies-literature
UnknownSex differences in voluntary running behavior between C57BL/6 and BALB/cJ mouse strains do not correspond to changes in VO2 and RER.
Not available
S-EPMC12513855 | biostudies-literature
TranscriptomicsGene Expression differences between replication error deficient and proficient colorectal cancers: the dominant role of deletions in 3’UTR poly T sequences
16 replication error proficient (RER-/MSI-) and 14 replication error deficient (RER+/MSI+) colorectal cancer cell lines Replication error deficient (RER+) colorectal cancers are a distinct subset of colorectal cancers, characterised by inactivation of the DNA mismatch repair system. They are typica...
ORGANISM(S): Homo sapiens 
2010-10-19 | E-GEOD-24795 | biostudies-arrayexpress
ProteomicsMulti-omics characterization of recurrent exertional rhabdomyolysis in Standardbred horses
During an episode of acute rhabdomyolysis, a microarray study identified differential expression of calcium-regulatory, mitochondrial and metabolic genes in gluteal muscle of Standardbreds. Whether this represents expression related to acute myodegeneration or a specific molecular signature of susce...
ORGANISM(S): Equus caballus (Horse) 
2023-03-11 | PXD026121 | Pride
Muscle disease Myopathy Tying-up Equine 
TranscriptomicsGene Expression differences between replication error deficient and proficient colorectal cancers: the dominant role of deletions in 3’UTR poly T sequences
16 replication error proficient (RER-/MSI-) and 14 replication error deficient (RER+/MSI+) colorectal cancer cell lines Replication error deficient (RER+) colorectal cancers are a distinct subset of colorectal cancers, characterised by inactivation of the DNA mismatch repair system. They are typical...
ORGANISM(S): Homo sapiens 
2010-10-19 | GSE24795 | GEO
TranscriptomicsTranscriptome analysis of muscle in horses suffering from recurrent exertional rhabdomyolysis revealed energetic pathway alterations and disruption in the cytoplasmic calcium regulation
The purpose of this study was to compare the gene expression profile of recurent exercise rhabdomyolysis vs control muscles in French Trotter to determine any metabolic or structural disorder. Transcriptome analysis revealed 191 genes significantly modulated in rhabdomyolysis vs control muscles (p<...
ORGANISM(S): Equus caballus 
2010-12-15 | E-GEOD-26047 | biostudies-arrayexpress
TranscriptomicsRibonucleotide excision repair is essential to prevent skin cancer [CD45+ CD49f- epidermal cells]
Large numbers of ribonucleotides are incorporated into the eukaryotic nuclear genome during S-phase due to imperfect discrimination against ribonucleoside triphosphates by the replicative DNA polymerases. Ribonucleotides, by far the most common DNA lesion in replicating cells, destabilize the DNA, a...
ORGANISM(S): Mus musculus 
2019-05-29 | GSE115004 | GEO
TranscriptomicsRibonucleotide excision repair is essential to prevent skin cancer [CD49f+ epidermal cells]
Large numbers of ribonucleotides are incorporated into the eukaryotic nuclear genome during S-phase due to imperfect discrimination against ribonucleoside triphosphates by the replicative DNA polymerases. Ribonucleotides, by far the most common DNA lesion in replicating cells, destabilize the DNA, a...
ORGANISM(S): Mus musculus 
2019-05-29 | GSE115003 | GEO
ProteomicsProteomics analysis of rough endoplasmic reticulum in pancreatic beta cells
Pancreatic beta cells have well-developed endoplasmic reticulum (ER) to accommodate for the massive production and secretion of insulin. ER homeostasis is vital for normal beta cell function. Perturbation of ER homeostasis contributes to beta cell dysfunction in both type 1 and type 2 diabetes. To s...
ORGANISM(S): Mus musculus (Mouse) 
2015-04-15 | PXD001081 | Pride
Insulin biogenesis Pancreatic beta cells Endoplasmic reticulum Gelc-ms/ms 
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