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TranscriptomicsResistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in proximal colon of male pigs
Consumption of resistant starch (RS) has been associated with various intestinal health benefits, but knowledge on its effects on global gene expression in the colon is limited. The main objective of the current study was to identify genes affected by RS in the proximal colon to infer which biologic...
ORGANISM(S): Sus scrofa 
2013-10-18 | E-GEOD-45554 | biostudies-arrayexpress
ProteomicsMetaproteomics of the Resistant Starch-fed Chronic Kidney Disease Rats
Background- Resistant starch is a prebiotic metabolized by the gut bacteria. It has been shown to attenuate chronic kidney disease (CKD) progression in rats. Previous studies employed taxonomic analysis using 16S rRNA sequencing and untargeted metabolomics profiling. Here we expand these studies by ...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-18 | PXD008845 | Pride
Chronic kidney disease Resistant starch Rat Gut microbiome Metaproteomics 
MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
Proteomicsimpacts of resistant starch fermentation in ex vivo microbiomes of pediatric IBD patients
Interindividual variability in responses to prebiotic fibers is an obstacle to improving health via microbiome modulation. Recent advances in ex vivo screening have enabled the personalized selection of prebiotics. This approach, when integrated with meta-omic analyses, hold the potential to unveil ...
ORGANISM(S): Homo sapiens (Human) Bacteria 
2026-09-07 | PXD048985 | Pride
Ibd Resistant starch Microbiomes 
ProteomicsInvestigation of Resistant Starch effect on gut microbiome in 5/6 nephrectomy mouse model of Chronic Kidney Disease
Background. Resistant Starch (RS) improves CKD outcomes. In this report we study how RS modulates host-microbiome interactions in CKD by measuring changes in abundance of proteins and bacteria in the gut. In addition, we demonstrate RS-mediated reduction in CKD-induced kidney damage. Methods. Eight...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-19 | PXD019623 | Pride
Mouse Microbiome Kidney Metaproteomics 
ProteomicsBifidobacterial genes upregulated by resistant starch investigated using multi-omics have orthologs in infant gut isolates
Bifidobacterium species and strains are key members of the human gut microbiota, appearing soon after birth and persisting into adulthood. Resistant starch is an important dietary substrate for adult-associated bifidobacteria, where its fermentation supports host health. However, less is known about...
ORGANISM(S): Bifidobacterium pseudolongum subsp. globosum DSM 20092 Bacteria 
2026-06-22 | PXD056548 | Pride
Resistant starch Alpha amylase Bifidobacteria Microbiome Weaning Microbiota Cazyme 
GenomicsJanssen Resistant Starch
Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome
PRJEB22786 | ENA
ProteomicsLoss of AA13 LPMOs impairs degradation of resistant starch and reduces the growth of Aspergillus nidulans
Background Lytic polysaccharide monooxygenases (LPMOs) are often studied in simple models involving activity measurements of a single LPMO or a blend thereof with hydrolytic enzymes towards an insoluble substrate. However, the contribution of LPMOs to polysaccharide breakdown in complex cocktails of...
ORGANISM(S): Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 
2020-09-02 | PXD020101 | Pride
Lpmo Lc-msms Aspergillus 
ProteomicsSpatial constraints drive amylosome-mediated resistant starch degradation by Ruminococcus bromii in the human colon
Degradation of complex dietary fibers by gut microbes is essential for colonic fermentation, short-chain fatty acid production, and microbiome function. Ruminococcus bromii is the primary resistant starch (RS) degrader in humans, which relies on the amylosome, a specialized cell-bound enzymatic comp...
ORGANISM(S): Ruminococcus bromii L2-63 
2025-11-02 | PXD060149 | Pride
Cryo-et Cell-associated proteome Structure Cohesin Dockerin 
TranscriptomicsRNA-seq of Ruminococcus bromii L2-63 and Ruminococcus gnavus ATCC 29149 grown in mono- or co-culture with different carbon sources (glucose, soluble or resistant starch)
The goal was to assess the impact of carbon source and cross-feeding on transcription profile of both bacteria. R. gnavus was grown in monoculture with glucose (Glc). R. bromii was grown in monoculture with soluble (SS) or resistant (RS) starch. R. bromii and R. gnavus were co-cultured with SS or RS...
ORGANISM(S): Ruminococcus bromii 
2019-07-31 | E-MTAB-7138 | biostudies-arrayexpress
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