Retinopathy - OmicsDI

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Unknown (6081)
Transcriptomics (473)
Genomics (456)
Proteomics (93)
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Genomic (12)
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Methylation profiling (5)
Clinical (1)

Organisms

Homo sapiens (258)
Mus musculus (196)
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synthetic construct (8)
Lodderomyces elongisporus NRRL YB-4239 (5)
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Candidozyma auris (1)
Butyrivibrio proteoclasticus B316 (1)
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Fusarium oxysporum (1)

Organisms

Mus musculus (127)
Homo sapiens (124)
Rattus norvegicus (18)
Danio rerio (4)
Macaca fascicularis (2)
human gut metagenome (2)
Arvicanthis niloticus (1)
synthetic construct (1)
human feces metagenome (1)

Repository

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biostudies-arrayexpress (301)
geo (253)
pride (59)
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dbGaP (12)
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GNPS (3)
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PanoramaPublic (2)
ExpressionAtlas (1)
GPMDB (1)
jPOST (1)
MetabolomicsWorkbench (1)
PAXDB (1)
PeptideAtlas (1)

Tissue

Retina (16)
Vitreous humor (13)
Cell culture (6)
Epithelial cell (5)
Blood plasma (3)
Saliva (3)
Embryonic stem cell (2)
Tear (2)
Blood (1)
Eye (1)
Anterior chamber of the eye (1)
Blood (1)
Blood cell (1)
Blood vessel endothelial cell (1)
Brain (1)
Choroid (1)
Choroidal cell of the eye (1)
Eye (1)
Glial cell (1)
Microglial cell (1)
Microvascular endothelium (1)
Muller cell (1)
R1 photoreceptor cell (1)
Retinal blood vessel endothelial cell (1)
Retinal cell (1)
Retinal microvascular endothelial cell (1)
Retinal pigment epithelium (1)
Retinal pigment epithelium cell (1)
Urine (1)
Venom (1)

Disease

Diabetic retinopathy (9)
Age related macular degeneration (5)
Proliferative diabetic retinopathy (5)
Diabetes mellitus (4)
Retinopathy of prematurity (3)
Normal (2)
Disease free (2)
Insulin resistance (1)
Type II diabetes mellitus (1)
Type I diabetes mellitus (1)
High bone mineral density (1)
Photoreceptor degeneration (1)
Retinitis pigmentosa (1)
Multi-pathological condition. According with Working Group of the Sociedad Española de Medicina Interna (SEMI), a patients are defined as multi-pathological or polypathological when they have chronic diseases that belong to two or more of the eight next categories:-Category A: NYHA heart failure class II (slight limitation of physical activity, in which ordinary physical activity causes dyspnea, angina, fatigue or palpitations). Ischemic heart disease.- Category B: Vasculitis and systemic autoimmune diseases. Chronic kidney disease defined by elevated creatinine (>1.4 mg/dL in men or >1.3 mg/dL in women) or proteinuria (albumin/creatinine ratio >300 mg/g, microalbuminuria >3mg/dL in urine sample or albumin >300 mg/day in 24-hour urine, for 3 months).- Category C: Chronic respiratory disease classified as MCR grade 2 (unable to keep the pace of another person of the same age (1)
Not Available (1)
Eye disease (1)
Age related macular degeneration 1 (1)
Alzheimer's disease (1)
Diabetes (1)
Diabetic angiopathy (1)
Epiretinal membrane (1)
Macular holes (1)
Permanent neonatal diabetes mellitus (1)
Retinal degeneration (1)
Retinal detachment (1)
Retinopathy (1)
Type 1 diabetes mellitus (1)
Type 2 diabetes mellitus (1)

Technology Type

Mass Spectrometry (60)
Shotgun proteomics (29)
Mass spectrometry (17)
Bottom-up proteomics (16)
Data-dependent acquisition (9)
Mass spectrometry assay (8)
Data-independent acquisition (6)
Gel-based experiment (6)
SWATH MS (5)
Illumina HiSeq 2500 (ILLUMINA) (2)
Illumina (2)
Top-down proteomics (2)
AB SOLiD 4 System, Illumina HiSeq 2000 (1)
ESI (1)
Affinity purification coupled with mass spectrometry proteomics (1)
MSE (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (36)
BGISEQ-500 (14)
Illumina HiSeq 4000 (11)
Illumina NovaSeq X (9)
NextSeq 500 (9)
DNBSEQ-T7 (8)
NextSeq 550 (8)
Illumina HiSeq 2500 (8)
Illumina HiSeq 2000 (5)
NextSeq 2000 (4)
Illumina MiSeq (4)
Agilent SureScan Microarray Scanner G2600D (1)
Lipofectamine RNAiMax transfection reagent (Invitrogen) (1)
CO₂ incubator (Thermo Fisher Scientific) (1)
Illumina TruSeq Stranded mRNA Library Prep Kit (1)
Agilent 2100 Bioanalyzer; Illumina TruSeq Stranded mRNA Prep Kit (1)
Biological safety cabinet (Thermo Fisher Scientific) (1)
Agilent 2100 Bioanalyzer (Agilent Technologies); Qubit Fluorometer (Thermo Fisher Scientific); standard electrophoresis system (1)
NanoDrop spectrophotometer, Agilent 2100 Bioanalyzer (1)
Thermal cycler, Agilent BioAnalyzer 2100 (1)
Microcentrifuge, vortex spinner, pipettes, -80C freezer (1)
Zeiss Stereomicroscope, standard lab plasticware (1)
Covaris sonicator, PCR thermocycler, magnetic rack for SPRI bead clean-up (1)
Liquid-nitrogen mortar and pestle, benchtop microcentrifuge, vortex mixer (1)
Dissecting tools, liquid nitrogen, −80 °C freezer (1)
Controlled-environment growth chamber (short-day; 8 h light / 16 h dark) (1)
Linux server, HPC cluster (1)
Not applicable in this study (1)
Thermal cycler (Bio-Rad C1000), Agilent 2100 Bioanalyzer, Qubit 4 Fluorometer (1)
Benchtop centrifuge, vortex, NanoDrop or plate reader (for RiboGreen assay), TapeStation (Agilent) (1)

Publication Date

2026 (102)
2025 (87)
2024 (84)
2023 (48)
2022 (44)
2010 (33)
2021 (31)
2015 (29)
2014 (29)
2013 (26)
2020 (22)
2019 (22)
2016 (22)
2008 (20)
2011 (17)
2012 (16)
2017 (11)
2009 (9)
2007 (9)
2018 (9)
2006 (2)
2005 (2)
2001 (1)

UNIPROT ID/AC

1433B_HUMAN (1)
1433E_HUMAN (1)
1433F_HUMAN (1)
1433G_HUMAN (1)
1433S_HUMAN (1)
1433T_HUMAN (1)
1433Z_HUMAN (1)
6PGD_HUMAN (1)
6PGL_HUMAN (1)
9606.ENSP00000322421 (1)
9606.ENSP00000347168 (1)
9606.ENSP00000348924 (1)
9606.ENSP00000352119 (1)
9606.ENSP00000352627 (1)
9606.ENSP00000356391 (1)
9606.ENSP00000366679 (1)
9606.ENSP00000366956 (1)
9606.ENSP00000366962 (1)
9606.ENSP00000366974 (1)
9606.ENSP00000367034 (1)
9606.ENSP00000382982 (1)
9606.ENSP00000415840 (1)
9606.ENSP00000417240 (1)
9606.ENSP00000421191 (1)
9606.ENSP00000443017 (1)
9606.ENSP00000445633 (1)
9606.ENSP00000450540 (1)
9606.ENSP00000462355 (1)
9606.ENSP00000462667 (1)
9606.ENSP00000464265 (1)

ENSEMBL ID

ENSG00000170477 (1)

CHEBI ID

CHEBI:16708 (3)
CHEBI:28044 (3)
CHEBI:6650 (3)
CHEBI:15428 (3)
CHEBI:27897 (3)
CHEBI:17895 (3)
CHEBI:17295 (3)
CHEBI:30769 (3)
CHEBI:28800 (2)
CHEBI:17992 (2)
CHEBI:37998 (2)
CHEBI:180956 (2)
CHEBI:16325 (2)
CHEBI:16755 (2)
CHEBI:9907 (2)
CHEBI:28300 (2)
CHEBI:16525 (2)
CHEBI:25017 (2)
CHEBI:72651 (2)
CHEBI:37654 (2)
CHEBI:16000 (2)
CHEBI:30746 (2)
CHEBI:17497 (2)
CHEBI:28834 (2)
CHEBI:16359 (2)
CHEBI:80774 (2)
CHEBI:16704 (2)
CHEBI:16857 (2)
CHEBI:17750 (2)
CHEBI:340824 (2)

Metabolite Name

Tryptophan (4)
Pyroglutamic acid (3)
Malic acid (3)
Phenylalanine (3)
Adenine (3)
L-Tyrosine (3)
D-Galactose (2)
Glucose-6-phosphate (2)
Erythronic acid (2)
Adenosine 5'-monophosphate (2)
Leucine (2)
GLCA (2)
TLCA (2)
GDCA (2)
GCDCA (2)
TDCA (2)
TCDCA (2)
TUDCA (2)
GCA (2)
TCA (2)
LCA (2)
DCA (2)
CDCA (2)
UDCA (2)
CA (2)
Glycine (2)
L-Alanine (2)
Uracil (2)
Valine (2)
Citrulline (2)

First Public Date

2024 (61)
2025 (56)
2026 (44)
2023 (43)
2022 (36)
2021 (32)
2020 (23)
2019 (18)
2014 (17)
2017 (7)
2015 (7)
2018 (5)
2016 (5)
2013 (3)

Study status

Not yet recruiting (1)

Study type

Transcription profiling by array (124)
RNA-seq of coding RNA (76)
DNA-seq (21)
RNA-seq of non coding RNA (13)
RNA-seq of total RNA (8)
Comparative genomic hybridization by array (7)
ChIP-seq (6)
Methylation profiling by array (5)
RNA-seq of coding RNA from single cells (5)
Unknown experiment type (4)
ChIP-chip by tiling array (4)
Spatial transcriptomics by high-throughput sequencing (3)
MicroRNA profiling by array (3)
Methylation profiling by high throughput sequencing (3)
Transcription profiling by SAGE (2)
Genotyping by array (2)
ATAC-seq (2)
Other (2)
Cell line - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
ChIP-chip by array (1)
Capture-C (1)
MicroRNA profiling by high throughput sequencing (1)
4C (1)
Exome sequencing (1)
RIP-seq (1)
Proteomic profiling by array (1)
CUT&RUN (1)
Interventional (1)

Release Date

2022 (792)
2025 (770)
2024 (699)
2023 (697)
2021 (664)
2020 (517)
2019 (375)
2018 (320)
2017 (263)
2016 (241)
2015 (190)
2014 (163)
2026 (155)
2013 (140)
2010 (78)
2011 (77)
2012 (76)
2009 (55)
2008 (44)
2007 (29)
2004 (8)
2005 (7)
2006 (6)
2001 (4)
2003 (4)
2002 (3)
2000 (2)
1999 (2)
1991 (1)

Lab affiliation

Boston Children's Hospital (3)
University of Malaya (3)
School of Optometry, The Hong Kong Polytechnic University (2)
1Department of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. (1)
1Research Unit Protein Science and Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany (1)
Associate Professor - Regional Centre for Biotechnology(RCB) 36 Faridabad, Delhi-NCR, India (1)
Barbara M. Braunger, Institute of Neuroanatomy, University Clinic Hamburg-Eppendorf, Hamburg, Germany (1)
Cedars-Sinai, Neurosurgery - Pavilion, 127 S San Vicente Blvd #A6600, Los Angeles, CA, 90048 (1)
College of Medicine University of Arkansas for Medical Science (1)
College of Pharmacy, Gachon University (1)
Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong S.A.R., China (1)
Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College (1)
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (1)
Department of Ophthalmology, Laboratory of Molecular Ophthalmology and Tianjin Key Laboratory of Ocular Trauma, Ministry of Education International Joint Laboratory of Ocular Diseases, Tianjin Medical University General Hospital; Tianjin 300052, China. (1)
Department of Ophthalmology, Penn State College of Medicine (1)
Department of Ophthalmology, Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases (1)
Department of Ophthalmology, Shanghai General Hospital; Shanghai Key Laboratory of Ocular Fundus Disease; Shanghai Engineering Center for Visual Science and Photomedicine, No. 100 Haining Road, Shanghai 200080, China. (1)
Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, China (1)
Department of Opthalmology, Boston Children's Hospital, Harvard Medical School (1)
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo (1)
Dept. of Ophthalmology, Visual and Anatomical Sciences Wayne State University School of Medicine (1)
Director, UAB CCC Proteomics Facility; Professor, UAB Anesthesiology (1)
Director, UAB CCC Proteomics Facility; Professor, UAB Anetsthesiology (1)
Experimental Pharmacology Mannheim, European Center of Angioscience, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany (1)
Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, (1)
Functional Proteomics Laboratory, Centro Nacional de Biotecnología, CSIC, Calle Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain. (1)
Hopital Ophtalmique Jules-Gonin Group « Macular Degeneration and Diabetic Retinopathy » Av. de France 15 1002 Lausanne Switzerland (1)
IRCCS Fondazione Bietti, Rome (1)
Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College (1)
Kyung Hee University (1)

Location

Colombia (1)

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Modification of erythrocyte membrane phospholipid composition in preterm newborns with retinopathy of prematurity: The omegaROP study

N-3 polyunsaturated fatty acids (PUFAs) may prevent retinal vascular abnormalities observed in oxygen-induced retinopathy, a model of retinopathy of prematurity (ROP). In the OmegaROP prospective cohort study, we showed that preterm infants who will develop ROP accumulate the n-6 PUFA arachidonic...

2022-09-07 | MTBLS4219 | MetaboLights

Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity

We determined which metabolic pathways are activated by hypoxia-inducible factor 1-mediated (HIF-1-mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading cause of infant blindness. HIF-1 coordinates the chang...

2019-07-05 | MTBLS856 | MetaboLights

Urea cycle and 1C/serine metabolism in the prevention of oxygen induced retinopathy

Not available

ORGANISM(S): Mus musculus

ST001130 | MetabolomicsWorkbench

Gene expression microarray analysis of early oxygen-induced retinopathy (OIR)

Different inbred strains of rats differ in their susceptibility to OIR, an animal model of human retinopathy of prematurity. We examined gene expression profiles in Fischer 344 (F344, resistant to OIR) and Sprague Dawley (SD, susceptible to OIR) rats at the early time point of day 3 to identifying g...

ORGANISM(S): Rattus norvegicus

2009-11-12 | E-GEOD-18998 | biostudies-arrayexpress

Salivary biomarkers of diabetic retinopathy, part 1

To characterize human salivary proteome and determine changes in proteins expression in different stages of diabetic retinopathy.

ORGANISM(S): Homo sapiens (Human)

2016-04-26 | PXD003723 | Pride

The role of insulin resistance in experimental diabetic retinopathy - genetic and molecular aspects

Patients with long-duration diabetes develop cardiovascular complications resulting in highly increased mortality and complications which affect the kidneys, eyes and peripheral nerves associated with high morbidity. Among the diabetic complications, damage in the eye, diabetic retinopathy, is the m...

ORGANISM(S): Rattus norvegicus

2017-03-31 | E-MTAB-5563 | biostudies-arrayexpress

Proteomics in exploring the endothelial dysfunction mechanism induced by serum exosomes from diabetic retinopathy and diabetic nephropathy patients

In this study, we used human glomerular endothelial cells (HGECs) as cells model, proteomics TMT-based LC-MS/MS was employed to discover the underlying mechanisms of endothelial dysfunction caused by SExos from diabetic retinopathy and nephropathy patients.

ORGANISM(S): Homo Sapiens

2021-12-29 | PXD030660 |

Putative tear fluid biomarkers of diabetic retinopathy

Identification of tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology of the disease...

ORGANISM(S): Homo sapiens (Human)

2022-05-31 | PXD033101 | Pride

Human Lc-msms Type 2 diabetes Proliferative diabetic retinopathy Nonproliferative diabetic retinopathy Tear fluid

Extracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients analyzed using mass spectrometry

Diabetic Retinopathy (DR) is a potentially blinding retinal disorder which develops through the pathogenesis of diabetes. Extracellular Vesicles (EVs) provide a novel biomarker for pre-symptomatic disease diagnosis and prognosis. Proteomic analysis was performed on explanted DR retinal tissue, DR r...

ORGANISM(S): Homo sapiens (Human)

2022-12-31 | PXD034626 | Pride

Lc-ms/ms Exosome Diabetic retinopathy

Single cell RNAseq of 12-week old AKIMBA versus WT mouse retina

Single-cell RNA sequencing was performed on retinal tissue from 12-week-old wild-type and Akimba (Ins2AkitaxVEGF+/-) mice, which are known to replicate features of clinical diabetic retinopathy. The aim of this study was to provide deeper insight into the complex network of molecular and cellular ch...

ORGANISM(S): Mus musculus

2020-05-23 | E-MTAB-9061 | biostudies-arrayexpress

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