Retinopathy of prematurity

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Serine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity

We determined which metabolic pathways are activated by hypoxia-inducible factor 1-mediated (HIF-1-mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading cause of infant blindness. HIF-1 coordinates the chang...

2019-07-05 | MTBLS856 | MetaboLights

Modification of erythrocyte membrane phospholipid composition in preterm newborns with retinopathy of prematurity: The omegaROP study

N-3 polyunsaturated fatty acids (PUFAs) may prevent retinal vascular abnormalities observed in oxygen-induced retinopathy, a model of retinopathy of prematurity (ROP). In the OmegaROP prospective cohort study, we showed that preterm infants who will develop ROP accumulate the n-6 PUFA arachidonic...

2022-09-07 | MTBLS4219 | MetaboLights

Gene expression microarray analysis of early oxygen-induced retinopathy (OIR)

Different inbred strains of rats differ in their susceptibility to OIR, an animal model of human retinopathy of prematurity. We examined gene expression profiles in Fischer 344 (F344, resistant to OIR) and Sprague Dawley (SD, susceptible to OIR) rats at the early time point of day 3 to identifying g...

ORGANISM(S): Rattus norvegicus

2009-11-12 | E-GEOD-18998 | biostudies-arrayexpress

Timed topical dexamethasone eye drops improve mitochondrial function to suppress severe retinopathy of prematurity.

Pathological neovascularization (NV) can cause visual impairment in retinopathy of prematurity (ROP). Current treatments addressing vasoproliferative (Phase II) ROP are costly and can lead to severe complications. We show that well-timed topical 0.1% dexamethasone eye drops during early retinal neov...

ORGANISM(S): Mus musculus (Mouse)

2025-05-07 | PXD052730 | Pride