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ProteomicsThe E3 ubiquitin ligase RFWD3 is required for translesion DNA synthesis (total proteome)
Lesions on DNA can uncouple DNA synthesis from helicase unwinding, generating stretches of unreplicated single stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication and thereby avoid the generation of DNA double-stranded breaks (DSBs), a ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-12-15 | PXD021445 | Pride
Chromass Tls Xenopus Rfwd3 Total proteome Dna Damage Ubiquitin Pcna Ts 
ProteomicsThe E3 ubiquitin ligase RFWD3 is required for translesion DNA synthesis
Lesions on DNA can uncouple DNA synthesis from helicase unwinding, generating stretches of unreplicated single stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication and thereby avoid the generation of DNA double-stranded breaks (DSBs), a ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-12-15 | PXD018217 | Pride
Chromass Tls Xenopus Rfwd3 Dna Damage Ubiquitin Pcna Ts 
GenomicsBiallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia
The WD40-containing E3 ubiquitin ligase RFWD3 has been recently linked to the repair of DNA damage by Homologous Recombination (HR). Here we show that an RFWD3 mutation within the WD40 domain is connected to the genetic disease Fanconi anemia (FA). An individual revealed congenital abnormalities cha...
EGAS00001002440 | EGA
UnknownBiallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.
Not available
S-EPMC5531404 | biostudies-literature
UnknownRFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma.
Not available
S-EPMC12021087 | biostudies-literature
UnknownThe ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Not available
S-EPMC7864614 | biostudies-literature
UnknownPCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication.
Not available
S-EPMC6310862 | biostudies-literature
UnknownUHRF1 Controls the Timing of RAD51 Removal During DNA Damage Repair Through Suppressing RFWD3.
Not available
S-EPMC12677587 | biostudies-literature
UnknownRPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.
Not available
S-EPMC5459755 | biostudies-literature
UnknownMicroRNA-190b Targets RFWD3 in Estrogen Receptor-Positive Breast Cancer.
Not available
S-EPMC10949548 | biostudies-literature
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