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ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
TranscriptomicsConstitutively active RhoA (RhoAV14) expression and regulation of acqeous humor outflow dynamics
Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPa...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-9288 | biostudies-arrayexpress
MetabolomicsXiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea via TGR5-FAK-RhoA/Rock signaling revealed by integrated metabolomics and proteomics

Irinotecan (CPT-11) is widely used for colorectal cancer treatment, with delayed-onset diarrhea as its primary side effect. Xiao-Chai-Hu-Tang (XCHT) has been clinically observed to alleviate diarrhea, but its mechanisms remain unclear. This study aimed to explore the underlying regulatory mechani...

2025-09-03 | MTBLS12931 | MetaboLights
TranscriptomicsTranscription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human normal and RhoA immortal cells
Rho family small GTPases serve as molecular switches in the regulation of diverse cellular functions including actin cytoskeleton remodeling, cell migration, gene transcription, and cell proliferation. Importantly, Rho overexpression is frequently seen in many carcinomas. However, published studies...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12917 | biostudies-arrayexpress
TranscriptomicsRHOA inactivation enhances Wnt signaling and promotes colorectal cancer
Microarray transcriptomic analysis of formalin-fixed, paraffin-embedded small intestinal tumors from control (Apcmin/+;Vil-Cre-/-;RhoADN/-) and DN-RhoA (Apcmin/+;Vil-CreTG/-;RhoADN/-) mice.
ORGANISM(S): Mus musculus 
2014-11-21 | E-MTAB-2981 | biostudies-arrayexpress
GenomicsRHOA Controls Oncogenic B-Cell Receptor Signaling in Aggressive Lymphoma
RHOA Controls Oncogenic B-Cell Receptor Signaling in Aggressive Lymphoma
PRJNA1312029 | ENA
GenomicsFoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer
PRJNA540152 | ENA
ProteomicsTaxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling
Taxanes are widely used chemotherapeutic agents that perturb cell division. They also exert effects during interphase, but the underlying mechanisms are poorly understood. Here, we show that taxanes activate RhoA signaling and induce actin remodeling by displacing the RhoA activator GEF-H1 from micr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-20 | PXD079708 | Pride
Rhoa signaling Gef-h1 Microtubules 
ProteomicsRhoA inhibitor treatment of spinal cord injury: Deep inside mechanism understanding for a better use
The present study shows by in vivo experiments, the impact of RhoA inhibitor treatment using a functionalized alginate scaffold and the beneficial results at the early stage by increasing neurites outgrowth and synaptic contact. However, 7 days after treatment a plateau is obtained in BBB score. We ...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-07-28 | PXD004639 | Pride
Spinal cord lesion Cd32 Anti-gfap Rhoa inhibitor Proteomic Transcriptomic factors In vivo studies Functionalized alginate Growth cone Immunoglobulins Neurites outgrowth 
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