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ProteomicsA Network G Protein Gai Signaling Partners is Revealed by Proximity Labeling Proteomics and Includes PDZ-RhoGEF
G protein-coupled receptors (GPCRs) that couple to the Gi family of G proteins are key regulators of cell and tissue physiology. Our previous work has revealed new roles for Gαi in regulating the migration of neutrophils and fibrosarcoma cells downstream of activated chemoattractant receptors. We us...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD027905 | Pride
Gαi proteins Proximity labeling Pdz-rhogef Cell-migration Interactome Mass spectrometry Gpcr signaling 
UnknownOncogenic Gαq activates RhoJ through PDZ-RhoGEF.
Not available
S-EPMC10647656 | biostudies-literature
UnknownThe evolutionary relationship of the domain architectures in the RhoGEF-containing proteins.
Not available
S-EPMC5172558 | biostudies-literature
UnknownDifferences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF.
Not available
S-EPMC2674241 | biostudies-literature
UnknownLeukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.
Not available
S-EPMC3771942 | biostudies-literature
UnknownCentralspindlin-mediated transport of RhoGEF positions the cleavage plane for cytokinesis.
Not available
S-EPMC10501416 | biostudies-literature
UnknownStructural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis.
Not available
S-EPMC3545058 | biostudies-literature
ProteomicsCoimmunoprecipitation and following mass spectrometry analysis of EhGEFM
To find out the binding partners of EhGEFM, crosslinking and coimmunoprecipitation were performed. Then, eluted samples were submitted to Mass Spectrometry and Proteomics Core Facility, Johns Hopkins University School of Medicine and analyzed by mass spctrometry (shotgun proteomics). The coimmunopre...
ORGANISM(S): Entamoeba histolytica HM-1:IMSS 
2026-05-16 | PXD068844 | Pride
Rho Ehgefm Entamoeba histolytica Co-ip Ehracm Rhogef 
UnknownPDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival.
Not available
S-EPMC6140379 | biostudies-literature
UnknownThe RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation.
Not available
S-EPMC2676674 | biostudies-literature
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