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ProteomicsIdentification of candidate interactors of Bacillus subtilis rhomboid protease YqgP
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity needs to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtil...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014566 | Pride
Transporter Intramembrane protease Co-immunoprecipitation Lipid membrane Rhomboid protease Proteostasis Lc-ms/ms 
ProteomicsRhomboid mediates membrane protein quality control as an intramembrane protease and adaptor of AAA protease.
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtili...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014578 | Pride
Transporter Er associated degradation Intramembrane protease Manganese Tripletof 5600 Magnesium Bacillus subtilis Lipid membrane Gelc-ms/ms Rhomboid protease Proteostasis Zinc 
ProteomicsHaloferax volcanii Proteome Response to Deletion of a Rhomboid Protease Gene
Rhomboids are conserved intramembrane serine proteases involved in cell signaling processes. Their role in prokaryotes is scarcely known and remains to be investigated in Archaea. We previously constructed a rhomboid homologue deletion mutant (ΔrhoII) in Haloferax volcanii, which showed reduced moti...
ORGANISM(S): Haloferax volcanii DS2 
2020-05-14 | PXD011218 | Pride
Shotgun proteomics Archaea Haloferax volcanii Rhomboid protease Protease substrate 
ProteomicsA quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.
Rhomboids are intramembrane serine proteases conserved in all kingdoms of life. They regulate epidermal growth factor receptor signalling in Drosophila by releasing signalling ligands from their transmembrane tethers. Their functions in mammals are poorly understood, in part because of the lack of e...
ORGANISM(S): Homo sapiens (Human) 
2017-08-14 | PXD006716 | Pride
Proteomics Ectodomain shedding Intramembrane protease Epithelia Rhomboid protease Substrate 
GenomicsAryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease PfROM8 and cation channel PfCSC1.
Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease PfROM8 and cation channel PfCSC1
PRJEB87210 | ENA
ProteomicsThe trypanosome Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
: In the endoplasmic reticulum (ER), the ER-associated degradation (ERAD) pathway targets incorrectly folded and unassembled proteins into the cytoplasm for turnover by the proteasome. Previously, we showed that the ER-resident rhomboid protease RHBDL4, together with p97, mediates membrane protein d...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027346 | Pride
Intramembrane proteolysis / rhomboid family protein / er-associated protein degradation / prohibitin family proteins erlin1 and erlin2 / protein aggregates 
TranscriptomicsEffect of Rom1 silencing on gene expression in Entamoeba histolytica
Entamoeba histolytica trophozoites epigenetically silenced for ameobapore A (G3 parasites) were additionally silenced for the Rhomboid gene Rom1 (EHI_197460) using the mechanism outlined in Mirelman et al. Parasite. 2008 Sep;15(3):266-74 (PMID 18814693). Rom1 silencing was confirmed by RT-PCR. Gene ...
ORGANISM(S): Entamoeba histolytica 
2010-07-07 | E-GEOD-21522 | biostudies-arrayexpress
UnknownStructure and mechanism of rhomboid protease.
Not available
S-EPMC3668704 | biostudies-literature
GenomicsLoss of rhomboid protease RHBDL4 delays tumour initiation in a mouse model of breast cancer
Loss of rhomboid protease RHBDL4 delays tumour initiation in a mouse model of breast cancer
PRJNA1390244 | ENA
UnknownStructure of rhomboid protease in a lipid environment.
Not available
S-EPMC3093617 | biostudies-literature
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