Sort   by:  
 Page size 
ProteomicsSmall and large ribosomal subunit deficiencies lead to distinct gene expression signatures that reflect cellular growth rate
Levels of the ribosome, the conserved molecular machine that mediates translation, are tightly linked to cellular growth rate. In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels. Because gene expression defects resulting f...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2018-10-12 | MSV000083033 | MassIVE
ProteomicsSuppressed Protein Translation Caused by MSP-8 Defect Determines Fungal Multidrug Resistance with Fitness Cost
Antifungal resistance, particularly the rise in multidrug resistance, has become a critical public health concern, garnering substantial attention. In this study, we used experimental evolution with Neurospora crassa as a model and identified a novel multidrug-resistance gene, msp-8, which encodes a...
ORGANISM(S): Neurospora Crassa Or74a 
PXD054574 |
GenomicsExpression signatures of NGLY1 deficiency
N-Glycanase 1 (NGLY1) deficiency is a rare and complex genetic disorder. Although recent studies have shed light on the molecular underpinnings of NGLY1 deficiency, a systematic characterization of gene and protein expression changes in patient-derived cells has been lacking. Here, we performed RNA-...
EGAS00001005573 | EGA
TranscriptomicsTranscription profiling of mouse embryonic stem cells transfected with miR-10a or miR-10a-MUT shows that miR-10a interacts with the 5 prime untranslated region of mRNAs encoding ribosomal proteins and enhances their translation
MicroRNAs (miRNAs) are small RNAs that function as post-transcriptional regulators of gene expression. miRNAs affect a variety of signaling pathways and impaired miRNA regulation may contribute to the development of cancer and other diseases. We show that miRNA miR-10a interacts with the 5' untransl...
ORGANISM(S): Mus musculus 
2008-11-08 | E-MEXP-1375 | biostudies-arrayexpress
TranscriptomicsGene expression profile of rice shoot in response to macronutrient deficiency
Macronutrients are pivotal elements for proper plant growth and development. We performed microarray analysis of rice shoot under nitrogen (N), phosphorus (P), and potassium (K) deficiency conditions to obtain a global view of gene regulations associated with plant response to essential nutrients. W...
ORGANISM(S): Oryza sativa Japonica Group 
2015-08-12 | E-GEOD-66935 | biostudies-arrayexpress
ProteomicsBiallelic variants in the mitochondrial ribosomal protein MRPL49 cause combined oxidative phosphorylation deficiency
Combined oxidative phosphorylation deficiency (COXPD) is a rare, multisystem disorder that exhibits significant clinical and genetic heterogeneity. Through genome sequencing, we identified biallelic variants in MRPL49 in individuals from five unrelated families. These individuals presented a spectru...
ORGANISM(S): Homo sapiens (Human) 
2025-03-04 | PXD056347 | Pride
Perrault syndrome Rare disease Mitochondrial large ribosomal subunit Mrpl49 Mitoribosome Combined oxidative phosphorylation deficiency 
TranscriptomicsNew partners in regulation of gene expression: the Enhancer of Trithorax and Polycomb Corto interacts with methylated Ribosomal Protein L12 via its chromodomain.
Chromodomains are found in many regulators of chromatin structure. Most of them recognize methylated histones. Here, we investigate the role of the Corto chromodomain. This Drosophila melanogaster Enhancer of Polycomb and Trithorax is involved in both silencing and activation of gene expression. Ove...
ORGANISM(S): Drosophila melanogaster 
2012-09-05 | E-GEOD-38435 | biostudies-arrayexpress
GenomicsPDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5
PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5
PRJNA634665 | ENA
ProteomicsRibosomal protein deficiency generates proteotoxic stress that is alleviated by TOR inhibition
Ribosomes are multi-component molecular machines that synthesize all the proteins of living cells. Understandably, most genes encoding the protein components of ribosomes are essential. Reduction in gene dosage is often viable but deleterious and associated with human syndromes, collectively known a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-01-14 | PXD023021 | Pride
Eif2 Protein translation Diamond blackfan anemia Ribosomes Autophagy Rps23 Ribosomopathies Protein aggregates Tor Proteotoxic stress Apoptosis P62 Rps26 
Genomics
Transcriptome and translatome in the deficiency of ribosomal protein uS10 (RPS20) in human cells.
PRJNA976116 | ENA
Sort   by:  
 Page size