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ProteomicsData-independent acquisition protease-multiplexing enables increased proteome sequence coverage across multiple fragmentation modes
The use of multiple proteases has been shown to increase protein sequence coverage in proteomics experiments, but due to the additional sample preparation and analysis time required, it has not been widely adapted in routine proteomic workflows. While data-independent acquisition (DIA) has been prim...
ORGANISM(S): Homo sapiens (Human) 
2022-03-18 | PXD027242 | Pride
Dia Gluc Multiplexing Aspn 
ProteomicsComparative Analysis of T Cell Spatial Proteomics and the Influence of HIV Expression
As systems biology approaches to virology have become more tractable, it has become possible to analyze highly studied viruses such as HIV in new, unbiased ways, including spatial proteomics. We have employed here a differential centrifugation protocol to fractionate an inducible model of HIV-expres...
ORGANISM(S): Homo sapiens (Human) 
2022-01-16 | PXD029956 | Pride
Spatial proteomics Hiv-1 Lc-ms/ms 
ProteomicsReduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion
Autophagy is essential for protein quality control and regulation of the functional proteome. Failure of autophagy pathways with age contributes to loss of proteostasis in aged organisms and accelerates progression of age-related diseases. In this work, we show that activity of endosomal microautoph...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035128 | Pride
Autophagy Chaperones Aging Proteostasis Lc-ms/ms 
ProteomicsThe microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism
Efforts to identify anti-cancer therapeutics are attempted with in vitro models that do not match the microenvironmental characteristics of human tissues. Using biocompatible hydrogels that mimic healthy or cancerous tissues and conventional or physiologically relevant culture medium, we systematica...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD044309 | Pride
Ecm Metabolism Glycosylation Lc-ms/ms Mechanopharmacology 
ProteomicsSelective RNA sequestration in P-bodies regulates cell identity
Post-transcriptional regulation is pivotal in guiding the gene expression programs that instruct cell fate decisions. Recent studies emphasize the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, the functional roles of...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058827 | Pride
P-bodies Proteomics Stem cells 
ProteomicsThe Global Phosphorylation Landscape of SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 3 million people worldwide and caused over 200,000 deaths since it emerged in late 2019. There is an urgent need to develop therapies that can limi...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2020-07-06 | PXD019113 | Pride
Sars-cov-2 Proteomics Vero-e6 Phosphoproteomics Coronavirus Covid-19 
UnknownOne Year of Continuous Positive Airway Pressure Adherence Improves Cognition in Older Adults With Mild Apnea and Mild Cognitive Impairment.
Not available
S-EPMC7212768 | biostudies-literature
ProteomicsProteomic Organellar Mapping Identifies Modulation of Peroxisomes by HIV-1
The interaction between HIV-1 and the host cell has been studied at many levels, but cell-wide organellar changes caused by the virus have not been defined. Here, we aimed to detail perturbations to the host cell spatial proteome following HIV protein expression. Subcellular fractionation followed b...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD024716 | Pride
Lc-ms/ms Organelle mapping Proteomics Hiv-1 
ProteomicsTax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages
Crosstalk between autophagy, host cell death, and inflammatory host responses to bacterial pathogens enables effective innate immune responses that limit bacterial growth while minimizing coincidental host damage. Mycobacterium tuberculosis (Mtb) thwarts innate immune defense mechanisms in alveolar ...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-15 | PXD064244 | Pride
Immune defense . mycobacterium tuberculosis Lc-msms 
ProteomicsThe Global Phosphorylation Landscape of SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 3 million people worldwide and caused over 200,000 deaths since it emerged in late 2019. There is an urgent need to develop therapies that can limi...
ORGANISM(S): Chlorocebus Aethiops (ncbitaxon:9534) 
2020-07-15 | MSV000085759 | MassIVE
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