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ProteomicsThe chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans
In this study, a GFP-tagged version of the protein HCF-1 was immuno-precipitated from C. elegans lysates of the strain IU171 and co-purifying proteins were identified by LC-MS/MS. As a negative control, the same immuno-precipitation was conducted from wild-type (strain N2) worms that did not carry a...
ORGANISM(S): Caenorhabditis elegans 
2024-01-29 | PXD047509 | Pride
Lc-msms C. elegans Immuno precipitation 
ProteomicsProteins and Molecular Pathways Relevant for Stemness Properties of Tumor-Initiating Pancreatic Cancer Stem Cells Recognized by Differential Proteome-, Gene Expression-, and Functional Analysis
Cancer stem cells (CSCs), a small subset of the tumor bulk with highly malignant properties, are deemed responsible for tumor initiation, growth, metastasis, and relapse. In order to reveal molecular markers and determinants of stemness properties, pancreatic CSCs were enriched in three-dimensional ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-25 | PXD018585 | Pride
Mrp14 Proteomics S100a9 Mac-2-bp Lgals3bp Pancreatic cancer stem cells S100a8 Mrp8 S100 proteins Functional assays Differential proteome analysis Tumor grafting model 
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