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ProteomicsRio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores
Kinetochores assemble on centromeres via histone H3 variant CENP-A and low levels of noncoding centromere transcripts (cenRNAs). The latter are ensured by transcription factor Cbf1 (S. cerevisiae), centromere-binding protein CENP-B (humans), and the local histone code downregulating RNA polymerase I...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD038337 | Pride
Rat1 Kinetochore Centromere Per centromere Riok1 Rio1 
ProteomicsRio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores
Kinetochores assemble on centromeres (CENs) via histone H3 variant CENP-A and low levels of CEN transcripts. RNA polymerase II (RNAPII) activity is restrained by the CEN histone code, while CEN RNA concentrations are reduced by the nuclear exosome. Using S. cerevisiae, we add kinase Rio1 to this sch...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-02-24 | PXD030623 | Pride
Rat1 Kinetochore Centromere Riok1 Pericentromere Rio1 
GenomicsThe global map of Rio1 activity in Saccharomyces cerevisiae
The global map of Rio1 activity in Saccharomyces cerevisiae
PRJNA419752 | ENA
ProteomicsProteomics analysis of human pre-40S ribosomal particles
Proteomics analysis of late human pre-40S particles purified using a catalytically-inactive RIO1 as bait. Analysis of RIO1(kd)-StHA pre-40S particles composition upon RPS26 depletion with siRNA.
ORGANISM(S): Homo sapiens (Human) 
2021-05-12 | PXD019270 | Pride
Ribosomal particles 
GenomicsRio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores
Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores
PRJNA904388 | ENA
TranscriptomicsDefining the Rio1 transcriptome in the yeast Saccharomyces cerevisiae
The conserved Saccharomyces cerevisiae kinase/ATPase Rio1 downregulates rDNA transcription to promote rDNA stability and segregation. To uncover additional roles in transcriptional regulation beyond the rDNA locus we defined the global Rio1 transcriptiome. By NGS we identify 818 differentially expre...
ORGANISM(S): Saccharomyces cerevisiae 
2018-06-14 | GSE70286 | GEO
GenomicsThe global map of Rio1 activity in Saccharomyces cerevisiae
In Saccharomyces cerevisiae, the kinase Rio1 regulates rDNA transcription and segregation, pre-rRNA cleavage, and 40S ribosomal subunit maturation. Other roles are unknown. Human orthologue RIOK1; which is frequently overexpressed in malignancies, drives tumor growth and metastasis. Again, also RIOK...
ORGANISM(S): Saccharomyces cerevisiae 
2020-11-23 | GSE107318 | GEO
UnknownThe Link between Protein Kinase CK2 and Atypical Kinase Rio1.
Not available
S-EPMC5374425 | biostudies-literature
UnknownRio1 mediates ATP-dependent final maturation of 40S ribosomal subunits.
Not available
S-EPMC4231747 | biostudies-literature
UnknownIntegrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae.
Not available
S-EPMC6125641 | biostudies-literature
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