Sort   by:  
 Page size 
ProteomicsYY1 interacts with promoter R-loops to regulate transcription
R-loops are three-stranded nucleic acid structures consisting of a DNA-RNA hybrid and a displaced single-stranded DNA (ssDNA). R-loops are facilitators of gene expression and genome stability that play both regulatory and potentially deleterious roles in cells. To elucidate the protein-based mechani...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD071221 | Pride
Lc-ms/ms Proximity proteomics Transcription regulation Yy1 R-loop 
ProteomicsR-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instabilityR-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
Transcription can pose a threat to genomic stability through the formation of R-loops that obstruct the progression of replication forks. R-loops are three-stranded nucleic acid structures formed by an RNA-DNA hybrid with a displaced non-template DNA strand. We developed RDProx to identify proteins ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD024517 | Pride
R-loop ddx41 
ProteomicsLoss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to Chromatin
Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stresses. HnRNP R has a diverse range of post-transcriptional regulatory functions and is important for neuronal development by regulating axon growth. Hnrnpr pre-mRNA undergoes a...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-01 | PXD022467 | Pride
Proteomics Hnrnpr Ip Ftld Als Motoneurons Dna damage response 
UnknownRipa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma.
Not available
S-EPMC10869350 | biostudies-literature
UnknownStructural snapshots along the reaction pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase.
Not available
S-EPMC3975890 | biostudies-literature
GenomicsHPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways
HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways
PRJNA1144451 | ENA
UnknownBiochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.
Not available
S-EPMC3180442 | biostudies-literature
UnknownThe antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3.
Not available
S-EPMC8901756 | biostudies-literature
GenomicsHPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways [gH2AX ChIP seq]
HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways [gH2AX ChIP seq]
PRJNA1144987 | ENA
GenomicsHPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways [H3K9me3 ChIP seq]
HPV induced R-loop formation represses innate immune gene expression while activating DNA damage repair pathways [H3K9me3 ChIP seq]
PRJNA1144988 | ENA
Sort   by:  
 Page size