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ProteomicsPrecisely measured protein lifetimes in the mouse
The turnover of brain proteins is critical for organism survival, and its perturbations are strongly linked to pathology. Nevertheless, precise protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically-labeled amino acids, followed...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-15 | PXD010859 | Pride
Neuron Ellps Cerebellum Metabolic labeling Brain turnover Cortex Protein lifetimes Glia 
UnknownDifferences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons.
Not available
S-EPMC8405817 | biostudies-literature
UnknownThe Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism.
Not available
S-EPMC3400554 | biostudies-literature
UnknownUllrich scleroatonic muscular dystrophy is caused by recessive mutations in collagen type VI.
Not available
S-EPMC34700 | biostudies-literature
UnknownCongenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis.
Not available
S-EPMC2427316 | biostudies-literature
ProteomicsWhite matter integrity requires continuous myelin synthesis at the inner tongue
Myelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. Using 3D electron microscopy, mass spectrometry imaging, and quantitative proteome analysis, we addressed the question how myelin function is affected by myelin turnover. We studie...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-14 | PXD025180 | Pride
Shiverer Myelin basic protein (mbp) Myelinoid body Juxtaparanode Myelin turnover Whole optic nerve proteome Optic nerve Fib-sem 3d reconstruction Nanosims 
ProteomicsCalcium-triggered (de)ubiquitination events in synapses
Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation cascades. However, little is known about other post-translational modifications, as ubiquitination. To address ...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
PXD053470 | panorama
ProteomicsIdentification of UFM1 candidate targets from mouse brain
Genetic variants that hinder post-translational protein modifications by the ubiquitin-like modifier UFM1 (UFMylation) cause encephalopathies. UFMylation regulates endoplasmic reticulum (ER) homeostasis, but how UFMylation-deficiencies cause selective neurological defects is unknown. In the framewor...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-28 | PXD071267 | Pride
Gel electrophoresis Brain Affinity purification Mass spectrometry Encephalopathy Ubiquitin-like modifier Ufm1 
UnknownTracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry.
Not available
S-EPMC10585107 | biostudies-literature
ProteomicsM.musculus - Cerebral cortex, SC (Fornasieroetal,natcomm2018)
abundance based on Spectral counting, Interaction consistency score: 8.0, Coverage: 7
ORGANISM(S): 10090 
2018-00-00 | 494884207 | PAXDB
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