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TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
GenomicsX-chromosome dynamics revealed by the RNA interactome and chromosomal binding of CTCF
CTCF is a master regulator that plays a role in genome architecture and gene expression. A key aspect of CTCF’s mechanism involves bringing together distant genetic elements for intra- and inter-chromosomal interactions. Evidence from epigenetic processes, such as X-chromosome inactivation (XCI), su...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-58242 | biostudies-arrayexpress
OtherInsights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Data from ProteomeXchange, PXD ID: PXD002880. Experiment: KS_A4_3, file: folder summary. Published as part of Cell. 2012 Jun 8;149(6):1393-406 . From the Abstract: {{i}} RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV cro...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM11210041750 | GPMDB
Resource Reanalysis 
TranscriptomicsLncPHx2 RNA-interactome
LncPHx2 RNA-interactome study realed that LncPHx2 is associated with multiple RNAs Biotinylated DNA probes targeting LncPHx2 were used to precipitate endogenous LncPHx2 and associated RNAs from Hepa 1-6 cells. The associated RNAs were sequenced and 415 unique transcripts were identified.
ORGANISM(S): Mus musculus 
2015-06-27 | E-GEOD-70342 | biostudies-arrayexpress
ProteomicsProfile of the SARS-CoV-2 RNA interactome
SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its ability to repurpose host RNA-binding proteins (RBPs) to form its own RNA interactome. Here, we developed and applied a robust ribonucleoprotein capture protocol to uncover the SARS-CoV-2 RNA interactome. We report 109 host factors...
ORGANISM(S): Homo sapiens (Human) Chlorocebus sabaeus 
2021-04-28 | PXD024808 | Pride
Hcov-oc43 Sars-cov-2 Hct-8 Vero Rnp Rna interactome Rbp 
ProteomicsProtein interactome of small RNA fragments: identification and functional implications
Populations of small eukaryotic RNAs, in addition to relatively well recognized molecules (such as miRNAs or siRNAs), also contain fragments derived from all classes of constitutively expressed non-coding RNAs. It has been recently demonstrated that the formation and accumulation of RNA fragments (R...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD010075 | Pride
Protein interactome Rna fragments Rna-protein interaction 
ProteomicsFAX-RIC enables robust RNA interactome profiling in multicellular organisms in vivo
Formaldehyde crosslinking based profiling of RNA interactome in the mosue tissue, liver.
ORGANISM(S): Mus musculus (Mouse) 
2020-11-25 | PXD022023 | Pride
Mouse liver rbp rna interactome 
ProteomicsThe concept of "RNA dependence" - Proteome-wide and quantitative identification of protein interactions dependent on RNA
The general role of RNA in the cell beyond protein biosynthesis is only beginning to emerge with little knowledge about the structural or organizational functions of RNA. In turn, functional non-coding RNAs (ncRNAs) are often identified by their regulation or impact on cellular phenotypes. However, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-06-13 | MSV000082468 | MassIVE
ProteomicsSerial interactome capture of the human cell nucleus
Novel RNA-guided cellular functions are paralleled by an increasing number of RNA binding proteins (RBPs). We present “serial interactome capture” (serIC), a multiple purification procedure of UV-crosslinked poly(A)-RNA-protein complexes that enables global RBP detection with maximal specificity. We...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080265 | MassIVE
UnknownRNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Not available
S-EPMC6204893 | biostudies-literature
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