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MetabolomicsGut Commensal Bacteria-Derived Methionine is Required for Host Reproduction by Modulating RNA m6A Methylation of the Insulin Receptor_targeted metabolites

Gut commensal bacteria promote host reproduction by modulating metabolism and nutrition, but the molecular mechanisms by which microbes regulate reproduction remain unclear. Here, we show that gut commensal bacteria promote host reproduction by providing amino-acid methionine, which controls the ...

2025-06-22 | MTBLS12470 | MetaboLights
TranscriptomicsSmall RNA mediated DNA (cytosine-5) methyltransferase 1 inhibition leads to aberrant DNA methylation
Mammalian cells contain copious amounts of RNA including both coding and non-coding RNA (ncRNA). Generally the ncRNAs function to regulate gene expression at the transcriptional and post-transcriptional level. Among ncRNA, the long ncRNA and small ncRNA can affect histone modification, DNA methylati...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-68027 | biostudies-arrayexpress
GenomicsCpG underrepresentation and the new bacterial CpG specific DNA methyltransferase M.MpeI
The CpG depleted Mycoplasma penetrans harbors a CpG specific C5 methyltransferase. The aim of this experiment was to confirm the specificity of the methyltransferase in vivo and in vitro. Genomic DNA from Mycoplasma penetrans and Escherichia coli genomic DNA that either was or was not methylated in ...
ORGANISM(S): Escherichia coli 
2012-11-29 | E-GEOD-41022 | biostudies-arrayexpress
ProteomicsRPL40 methyltransferase discovery and characterisation
The eukaryotic ribosome is highly modified by protein methylation, yet many of the responsible methyltransferases remain unknown. Here we have identified SMYD5 as a ribosomal protein methyltransferase that catalyses trimethylation of RPL40 at lysine 22. Through a systematic mass spectrometry-based a...
ORGANISM(S): Homo Sapiens 
PXD056489 | panorama
TranscriptomicsIdentification and Characterization of the Mammalian Nuclear RNA N6-Adenosine Methyltransferase Core Complex
N6-methyladenosine (m6A) is the most prevalent internal modification found in mammalian messenger and non-coding RNAs. The discoveries of functionally significant demethylases that reverse this methylation as well as the recently revealed m6A distributions in mammalian transcriptomes strongly indica...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-46705 | biostudies-arrayexpress
ProteomicsAged Mouse Muscle: Sedentary or Exercised Animals with or without Nicotinamide N-methyltransferase Inhibitor Treatment
Aged (22-mo) female mice (n=35), obtained from the US NIH National Institute on Aging (NIA) Aged Rodent Colony, were randomly assigned to one of four groups: saline-treated sedentary ( n=9), nicotinamide N-methyltransferase inhibitor (NNMTi)-treated sedentary (10 mg/kg body weight; n=9), saline-trea...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-05-07 | MSV000094700 | MassIVE
ProteomicsComprehensive Nucleoside Analysis of Archaeal RNA Modification Profiles Reveals a m7G in the Conserved P-loop of 23S rRNA
Extremophilic archaea employ diverse chemical RNA modifications, providing a rich source of new enzymes for biotechnologically valuable RNA manipulations. Our understanding of the modified nucleoside profiles in Archaea, as well as the functions and dynamic regulation of specific RNA modifications i...
ORGANISM(S): Thermococcus kodakarensis 
2025-02-12 | PXD060644 | Pride
Rna modifications Archaea Lc-ms/ms 
ProteomicsMethyltransferase-like 3 (METTL3) regulates exocytosis
RNA modification pathways are often mis-regulated in various typers of cancer, with N6-methyladenosine (m6A) playing a pivotal role in cancer progression and metastasis. Methyltransferase-like 3 (METTL3), a core component of the m6A methyltransferase complex, functions not only as an m6A writer but ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-04 | PXD066045 | Pride
Exoc7 Breast cancer Rna modification Vesicle trafficking Exocyst N6-methyladenosine Mettl3 
GenomicsSplicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 lysine 36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here we show that splicing can also contribute to histone modification, which implies a bidirectional communication between epigenetics and RNA processing. Genome-wide analysis of histone methylation in human cell ...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30902 | biostudies-arrayexpress
TranscriptomicsThe Wilms' tumour 1 transcription factor regulates epigenetic states via DNA methyltransferase 3A
The Wilms' tumour 1 transcription factor regulates epigenetic states via DNA methyltransferase 3A. The data consists of two Nimblegen promoter/CpG island microarrays hybridized with MCIP DNA immunoprecipitated from either a HEK293-derived cell line expressing a heterologous WT1 cDNA (W210) or a cont...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-39713 | biostudies-arrayexpress
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