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ProteomicsA systematic screen of archaeal MazF proteins reveals Tth-MazF1, a versatile, sequence-specific ribonuclease from Thermococcus thioreducens.
Nucleotide- and sequence-specific ribonucleases are essential tools for dissecting RNA structure, modification, and composition, yet the enzymatic repertoire available for high-resolution RNA analysis remains limited. Here, we systematically screened 186 MazF homologs, including 164 from archaeal or...
ORGANISM(S): Thermococcus thioreducens 
2026-05-25 | PXD067005 | Pride
Thermococcus thioreducens rna lc-ms/ms 
ProteomicsComprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5’ UTR of tumor-associated mRNAs
G-quadruplex structures in the 5’ UTR of mRNAs are widely considered to suppress translation without affecting transcription. The current study describes the comprehensive analysis of proteins binding to four different G-quadruplex motifs located in mRNAs of the cancer-related genes Bcl-2, NRAS, MMP...
ORGANISM(S): Homo sapiens (Human) 
2017-11-14 | PXD005761 | Pride
Nras Cancer Translational regulation Silac Mmp16 Rna Rbps Shotgun proteomics G-quadruplexes Bcl-2 Arpc2 Post-transcriptional regulation 
OtherInsights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Data from ProteomeXchange, PXD ID: PXD002880. Experiment: KS_A4_3, file: folder summary. Published as part of Cell. 2012 Jun 8;149(6):1393-406 . From the Abstract: {{i}} RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two complementary protocols for covalent UV cro...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM11210041750 | GPMDB
Resource Reanalysis 
ProteomicsMultiple intron motifs have redundant functions in trans-splicing of the mod(mdg4) locus
In contrast to canonical cis-splicing, trans-splicing combines exons from two distinct transcripts, yielding chimeric mRNAs. One striking example is the ubiquitously expressed modifier of mdg4 (mod(mdg4)) locus in Drosophila, where all mRNAs spanning over 30 isoforms are generated exclusively by tra...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-05-28 | PXD079014 | Pride
Rna motifs Alternative splicing Spliceosome Rna-binding proteins Trans-splicing Mod(mdg4) Drosophila melanogaster 
UnknownDotAligner: identification and clustering of RNA structure motifs.
Not available
S-EPMC5747123 | biostudies-literature
UnknownAutomated classification of RNA 3D motifs and the RNA 3D Motif Atlas.
Not available
S-EPMC3854523 | biostudies-literature
TranscriptomicsLIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance
This SuperSeries is composed of the following subset Series: GSE39855: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (splicing array) GSE39872: LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance (HTS) Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-09-10 | E-GEOD-39873 | biostudies-arrayexpress
UnknownEndo-bind-n-seq: identifying RNA motifs of RNA binding proteins isolated from endogenous sources.
Not available
S-EPMC11612968 | biostudies-literature
TranscriptomicsA compendium of RNA-binding motifs for analysis of gene regulation
RNA binding proteins are key regulators of gene expression, yet only a small fraction of these proteins has been functionally characterized. Here, we report the first large-scale analysis of the RNA motifs recognised by RNA binding proteins, encompassing 205 distinct proteins from 24 diverse eukary...
ORGANISM(S): synthetic construct 
2013-05-10 | E-GEOD-41235 | biostudies-arrayexpress
UnknownMethylation guide RNAs without box C/D motifs.
Not available
S-EPMC9670817 | biostudies-literature
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