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ProteomicsSurface and global proteome profiling of osteosarcoma patient derived xenografts
This study analyzed 22 unique OS patient-derived xenografts (PDXs) using proteomics to identify surface proteins for potential immunotherapeutic targeting. Plasma membranes were enriched using density gradient ultracentrifugation and compared to a reference standard of 12 immortalized non-OS cell li...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD075484 | Pride
Osteosarcoma 
ProteomicsGlobal proteome analysis of shROR2 MNNG cells
MNNG cells expressing a doxycycline (DOX)-inducible non-targeting shRNA (shCTRL) construct, or three independent shRNA constructs targeting ROR2 (shROR2 1, shROR2 2 and shROR2 3), were grown for 7 days in the presence of 5 µg/ml DOX prior to extraction.
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD077022 | Pride
Ror2 Osteosarcoma 
ProteomicsADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways
Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is enabled by its remarkable capacity to systematically subvert host immune defences. In exploring the finding that HCMV infection upregulates tumor necrosis factor receptor 2 (TNFR2), a ligand for the proinflammatory...
ORGANISM(S): Cytomegalovirus Homo sapiens (Human) 
2023-10-11 | PXD044082 | Pride
Ul148 Tnfr2 Immune Adam17 Natural killer cell Human cytomegalovirus 
ProteomicsProteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy
Platinum-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer (MIBC) despite modest survival benefit and significant associated toxicities. Here, we profiled the global proteome of MIBC tumours pre- and post-NAC treatment usin...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD049435 | Pride
Bladder cancer Mibc 
ProteomicsAdaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
Rare inherited diseases caused by mutations in the copper transporters SLC31A1 (CTR1) or ATP7A induce copper deficiency in the brain, causing seizures and neurodegeneration in infancy through poorly understood mechanisms. Here, we used multiple model systems to characterize the molecular mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD059097 | Pride
Tmt Neurodegeneration Mtor 
MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Human data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2015-10-05 | MTBLS162 | MetaboLights
TranscriptomicsTranscription profiling of human neuroblastoma samples to identify candidate genes by combining genomic and expression microarrays. Super series see E-GEOD-13136 and E-GEOD-13137
This SuperSeries is composed of the following subset Series:; GSE13136: Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data; GSE13137: Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP dat...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-13141 | biostudies-arrayexpress
UnknownEstrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy.
Not available
S-EPMC9388660 | biostudies-literature
UnknownCost Effectiveness of Pre- vs Post-Liver Transplant Hepatitis C Treatment With Direct-Acting Antivirals.
Not available
S-EPMC5733714 | biostudies-literature
UnknownCost Effectiveness of Transplanting HCV-Infected Livers Into Uninfected Recipients With Preemptive Antiviral Therapy.
Not available
S-EPMC6382534 | biostudies-literature
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