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ProteomicsMass spectrometry of neuroblastoma organoids
Collect proteomic data for organoids from relapsed neuroblastoma patients
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051208 | Pride
Neuroblastoma Dia Organoids 
MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
TranscriptomicsRNA-seq differential expression analysis of tmRNA (ssrA) mutants in the genome-reduced bacterium Mycoplasma pneumoniae
We used a combination of genetic and proteomic approaches to characterize tmRNA (ssrA) activity in the genome-reduced bacterium Mycoplasma pneumoniae. For this, we generated tmRNA mutants encoding a tag resistant to proteolysis. Endogenous protein tagging by the mutant tmRNA gene (ssrAmk) was then e...
ORGANISM(S): Mycoplasma pneumoniae 
2021-08-09 | E-MTAB-10111 | biostudies-arrayexpress
MetabolomicsThe impact of slyA on cell metabolism of Salmonella Typhimurium: a joint study of transcriptomics and metabolomics

Salmonella Typhimurium (S. typhimurium), a gram-negative foodborne pathogen, is the leading cause of Salmonella food poisoning in humans. slyA has been demonstrated to be a critical transcriptional regulator in S. typhimurium, enabling the pathogen to survive in host cells by modulating the expre...

2020-10-11 | MTBLS1858 | MetaboLights
ProteomicsProteomic profiling of idiopathic Parkinson’s disease primary patient cells by SWATH-MS
We performed Sequential Window Acquisition of all THeoretical Mass Spectra (SWATH-MS) on primary patient olfactory neuroepithelial derived cells (ONS) from both idiopathic PD (iPD) and healthy controls and identified 228 differentially quantified proteins. Reactome pathway analysis revealed that the...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030723 | Pride
Lc-ms/ms Swath Parkinson's 
Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsHuman cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 1A)
Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an ...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-37664 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from animals treated for 4 weeks with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-6511 | biostudies-arrayexpress
TranscriptomicsHuman cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2A)
Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an ...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-37670 | biostudies-arrayexpress
TranscriptomicsDiatom transcriptomics under nitrate limitation
Here, we examined the ramifications of between-species diversity by documenting the transcriptional response of three marine diatoms - Thalassiosira pseudonana, Fragilariopsis cylindrus, and Pseudo-nitzschia multiseries - to the onset of nitrate limitation of growth, a common limiting nutrient in th...
ORGANISM(S): Thalassiosira pseudonana 
2014-03-25 | E-GEOD-56132 | biostudies-arrayexpress
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