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ProteomicsThe surface proteome of extracellular vesicles from Fasciola hepatica
Helminth parasites secrete extracellular vesicles (EVs) as a means of exporting effector molecules into the host microenvironment. Once released, the parasite-derived EVs are internalised by host immune cells and trigger a range of biological effects including modulation of host immunity. While the ...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2019-11-12 | PXD007782 | Pride
Fasciola hepatica Exosome Extracellular vesicle 
GenomicsEvaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias and copy number variation
Abstract: DNA methylation is an essential epigenetic modification that plays a key role associated with the regulation of gene expression during differentiation but in disease states such as cancer, the DNA methylation landscape is often deregulated. There are now numerous technologies available to...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24546 | biostudies-arrayexpress
ProteomicsProteomics analysis of trematode eggshells
Trematodes such as the liver fluke Fasciola hepatica and the rumen fluke Calicophoron daubneyi are endemic throughout Europe where they tyically infect sheep and cattle. Adult fluke shed thousands of eggs which possess a tougher outer eggshell composed of cross-linked eggshell precursor (or vitellin...
ORGANISM(S): Calicophoron daubneyi Fasciola hepatica (Liver fluke) 
2024-12-18 | PXD053790 | Pride
Calicophoron daubneyi Eggshell Trematode Fasciola hepatica 
GenomicsBisulphite-sequencing of chromatin immunoprecipitated DNA (BisChiP-seq) directly informs methylation status
Bisulphite sequencing enables DNA methylation analysis of every cytosine residue. We have optimized conditions for combining chromatin immunoprecipation (ChIP) with high throughput bisulphite sequencing to study the relationship between histone modifications and DNA methylation. Paired-end bisulphit...
ORGANISM(S): Homo sapiens 
2012-01-18 | E-GEOD-30558 | biostudies-arrayexpress
Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsThe male determining M-factor of the global disease vector Musca domestica is a paralog of the generic splice factor CWC22
Sex determination mechanisms are bewilderingly diverse. A cascade of genes with hierarchical regulation characterizes sex determination pathways in insects. How such pathways evolve is poorly understood, partly due to a lack of comparative data. Houseflies are well known for their polymorphic sex d...
ORGANISM(S): Musca domestica 
2017-05-12 | E-MTAB-5080 | biostudies-arrayexpress
UnknownG-quadruplexes Mark Sites of Methylation Instability Associated with Ageing and Cancer.
Not available
S-EPMC9498706 | biostudies-literature
ProteomicsZebrafish 24hpf whole embryo MZezh2mutant
Polycomb group (PcG) proteins are transcriptional repressors important to maintain cell identity during embryonic development. Ezh2, the catalytic subunit of the Polycomb Repressive Complex 2, is responsible for placing the epigenetic repressive mark histone H3 lysine 27 trimethylation (H3K27me3). I...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2019-09-09 | PXD010922 | Pride
Embryo 24hpf Zebrafish Ezh2 
GenomicsDNA methylation analysis of prostate cancer cell lines and tissues using Next Generation Sequencing
Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation patterns in prostate tissues (n=17) and cells (n=2) from fifty nanograms of genomic DNA using Methylplex-Next Generation Sequencing (M-NGS). A...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-27618 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of proliferating cells in the mouse stomach corpus epithelium from FUCCI mouse.
The purpose of this bulk RNA-seq experiment is to identify candidate genes that can mark proliferating isthmus progenitors in the mouse stomach corpus epithelium. The cycling isthmus progenitors were isolated based on mVenus expression in FUCCI mouse and used for bulk RNA-seq data generation. The co...
ORGANISM(S): Mus musculus 
2019-08-14 | E-MTAB-6850 | biostudies-arrayexpress
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