Rock inhibitor - OmicsDI

Show results for

Transcriptomics (3056)
Genomics (1015)
Unknown (833)
Proteomics (98)
Other (4)
Metabolomics (4)
Methylation profiling (1)

Organisms

Homo sapiens (903)
Mus musculus (741)
Drosophila melanogaster (707)
Caenorhabditis elegans (255)
Saccharomyces cerevisiae (177)
Arabidopsis thaliana (126)
Rattus norvegicus (100)
Thermus thermophilus HB8 (68)
Escherichia coli (39)
Schizosaccharomyces pombe (38)
Danio rerio (31)
Rhizobium leguminosarum (30)
Mycobacterium tuberculosis (25)
Bos taurus (25)
Escherichia coli str. K-12 substr. MG1655 (25)
Zea mays (20)
Gallus gallus (20)
Taeniopygia guttata (14)
Streptomyces venezuelae (14)
Hordeum vulgare (13)
Plasmodium falciparum (13)
Listeria monocytogenes (12)
Salmonella enterica subsp. enterica serovar Typhimurium (12)
Escherichia coli K-12 (12)
Sus scrofa (12)
Oryza sativa (11)
Bacillus subtilis (11)
Staphylococcus aureus (11)
Candida albicans (11)
Triticum aestivum (10)

Organisms

Homo sapiens (49)
Mus musculus (12)
Danio rerio (2)
Staphylococcus aureus (1)
Sus scrofa (1)
Escherichia coli (1)

Repository

biostudies-arrayexpress (3988)
ENA (76)
geo (35)
pride (32)
MassIVE (30)
jPOST (19)
MetaboLights (4)
GPMDB (3)
EGA (2)
iProX (1)

Tissue

Cell culture (9)
Epithelial cell (4)
Fibroblast (3)
B cell (2)
Brain (2)
Early embryonic cell (2)
Embryo (2)
Embryonic stem cell (2)
Hepatocyte (2)
Kidney (2)
Permanent cell line cell (2)
Stem cell (2)
T cell (2)
Bone marrow (1)
Cecum (1)
Cell suspension culture (1)
Colon (1)
HiPSC cell (1)
Keratinocyte (1)
Leukocyte (1)
Liver (1)
Macrophage (1)
Microglia (1)
Microglial cell (1)
Monocyte (1)
Multipotent stem cell (1)
Neuronal stem cell (1)
Oocyte (1)
Pluripotent stem cell (1)
Saliva (1)

Disease

Normal (24)
Infiltrating ductal carcinoma (2)
Chronic myeloid leukemia (2)
Cancer (2)
Osteosarcoma (2)
None (2)
Neuroblastoma (2)
Tumor stage T2+ (1)
Invasive pituitary adenoma (1)
Post-stasis (1)
Blumeria graminis hordei (powdery mildew) inoculation (1)
Squamous cell carcinoma has accession C0007137 in DiseaseStateDatabase NCI_Thesaurus (1)
Malaria (1)
Pancreatic ductal adenocarcinoma (1)
Primary tumor (1)
Breast adenocarcinoma (1)
Porphyria NOS (1)
Infected (1)
Rheumatoid arthritis (1)
Colorectal cancer (1)
Osteosarcoma (1)
ARR1-SRDX (1)
None- acute control (1)
Squamous cell carcinoma (1)
IBDV infected (1)
Leukemia (1)
Hyperglycaemic (1)
Psoriasis (1)
Head and neck squamous cell carcinoma (1)
Neurological disease (1)

Technology Type

Mass Spectrometry (32)
Shotgun proteomics (18)
Bottom-up proteomics (8)
Mass spectrometry (4)
Data-independent acquisition (3)
Affinity purification coupled with mass spectrometry proteomics (2)
Data-dependent acquisition (2)
SWATH MS (2)
DiaPASEF (1)
Gel-based experiment (1)

Instrument Platform

NextSeq 500 (115)
Illumina NovaSeq 6000 (94)
Illumina HiSeq 2000 (81)
Illumina HiSeq 2500 (72)
Illumina HiSeq 4000 (55)
NextSeq 550 (46)
NextSeq 2000 (14)
Illumina MiSeq (14)
Illumina Genome Analyzer IIx (12)
Axon GenePix 4000B scanning hardware (11)
Illumina NovaSeq X (11)
Axon- GenePix4000B (9)
GenePix 4000B [Axon Instruments] (9)
Illumina Genome Analyzer II (9)
Illumina HiSeq 3000 (7)
Illumina HiSeq 1500 (6)
Generation III Array Scanner [Amersham] (5)
Scanning hardware (5)
Vortex (5)
NA (5)
Ultracentrifuge (4)
GenePix 4000A [Axon Instruments] (4)
Spectronic Helios Alpha UV-Vis spectrophotometer (4)
Other (4)
Element AVITI (3)
Axon GenePix4000B (3)
418 [Affymetrix] (3)
BGISEQ-500 (3)
HiSeq X Ten (3)
IEO HPC (2)

Publication Date

2013 (746)
2010 (557)
2011 (409)
2014 (368)
2012 (337)
2015 (307)
2016 (230)
2008 (144)
2009 (136)
2023 (87)
2007 (87)
2021 (82)
2022 (74)
2005 (70)
2025 (66)
2006 (63)
2018 (61)
2020 (58)
2024 (56)
2019 (53)
2026 (50)
2017 (49)
2004 (15)
2003 (1)
2002 (1)

CHEBI ID

CHEBI:116314 (2)
CHEBI:137056 (2)
CHEBI:137846 (2)
CHEBI:138421 (2)
CHEBI:141421 (2)
CHEBI:142245 (2)
CHEBI:143243 (2)
CHEBI:143726 (2)
CHEBI:145277 (2)
CHEBI:146162 (2)
CHEBI:149774 (2)
CHEBI:15354 (2)
CHEBI:15641 (2)
CHEBI:15741 (2)
CHEBI:15746 (2)
CHEBI:15891 (2)
CHEBI:15971 (2)
CHEBI:16015 (2)
CHEBI:16027 (2)
CHEBI:16235 (2)
CHEBI:16264 (2)
CHEBI:16283 (2)
CHEBI:16347 (2)
CHEBI:16393 (2)
CHEBI:16437 (2)
CHEBI:16467 (2)
CHEBI:165178 (2)
CHEBI:16543 (2)
CHEBI:165449 (2)
CHEBI:16566 (2)

Metabolite Name

12-amino-dodecanoic acid (2)
Aminoadipic acid (2)
Choline (2)
Creatine (2)
Methionine (2)
Proline (2)
Putrescine (2)
Spermidine (2)
Valine (2)
(+)-15,16-Dihydroxyoctadecanoic acid (1)
(+)-8'-hydroxyabscisic acid (1)
(+/-)-Hexanoylcarnitine (1)
(+/-)-threo-1-(p-Hydroxyphenyl)propylene glycol 4'-glucoside (1)
(+/-)18-HETE (1)
(-)-11-hydroxy-9,10-dihydrojasmonic acid 11-beta-d-glucoside (1)
(-)-Dihydrocarveol (1)
(-)-lupinine (1)
(-)-trans-Carveol glucoside (1)
(11z,14z)-eicosadienoylcarnitine (1)
(1s,2r)-1,2-dihydrodibenzo[b,d]thiophene-1,2-diol (1)
(1s,2r,3s,5s,6s,16e,18e,20r,21s)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,16-trimethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate (1)
(2,7-dimethyloctahydro-1h-cyclopenta[c]pyridin-4-yl)methanol (1)
(2e)-2-[(4z)-5-(methylsulfanyl)-4-penten-2-yn-1-ylidene]-1,6-dioxaspiro[4.4]non-3-ene (1)
(2r,3s)-2-methylcitric acid (1)
(2s,3r,4e,8e)-3-hydroxy-2-[methyl(stearoyl)amino]-4,8-octadecadien-1-yl hydrogen sulfate (1)
(2s,3s,4s,5r,6s)-6-(hydroxymethyl)-5-{[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)-5-{[(2r,3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl]oxy}tetrahydro-2h-pyran-2-yl]oxy}tetrahydro-2h-pyran-2,3,4,5-tetrol (1)
(2s,4ar,4br,6as,12bs,12cs,14as)-2-(2-hydroxy-2-propanyl)-12b,12c-dimethyl-3,4,5,6,6a,7,12,12b,12c,13,14,14a-dodecahydro-2h-chromeno[5',6':6,7]indeno[1,2-b]indole-4a(4bh)-carbaldehyde (1)
(2s,4s)-4-amino-2-hydroxy-2-methylpentanedioic acid (1)
(2s,4s)-pinnatanine (1)
(2z)-3-{5-[(4z)-5-(methylsulfanyl)-4-penten-2-yn-1-yl]-2-furyl}acrylaldehyde (1)

First Public Date

2025 (16)
2022 (12)
2014 (12)
2024 (11)
2026 (5)
2018 (5)
2019 (4)
2023 (3)
2021 (3)
2020 (2)
2016 (2)
2015 (1)

Classification

bacteria (2)

Study type

Transcription profiling by array (1236)
ChIP-seq (846)
ChIP-chip by tiling array (706)
RNA-seq of coding RNA (292)
ChIP-chip by array (169)
Other (114)
Comparative genomic hybridization by array (69)
RNA-seq of non coding RNA (65)
Methylation profiling by high throughput sequencing (64)
RNA-seq of coding RNA from single cells (53)
Methylation profiling by array (52)
Transcription profiling by tiling array (37)
DNA-seq (26)
Unknown experiment type (24)
Cell line - High-throughput sequencing (21)
CUT&RUN (21)
High-throughput sequencing (16)
RIP-seq (16)
ATAC-seq (15)
MicroRNA profiling by array (14)
Proteomic profiling by array (14)
Hi-C (12)
Animal - High-throughput sequencing (11)
CLIP-seq (10)
RNA-seq of total RNA (10)
Genotyping by array (6)
Ribo-seq (6)
Single nucleus RNA sequencing (6)
MNase-seq (5)
4C (4)

Release Date

2013 (781)
2010 (570)
2011 (423)
2014 (396)
2012 (356)
2015 (343)
2016 (270)
2021 (174)
2008 (153)
2009 (149)
2023 (136)
2020 (126)
2022 (117)
2025 (105)
2019 (105)
2024 (103)
2017 (103)
2018 (102)
2007 (93)
2005 (70)
2006 (63)
2026 (55)
2004 (19)
2003 (4)
2002 (3)
2000 (1)
1999 (1)

Lab affiliation

Institute of Cancer Research, Division of Cancer Biology, 237 Fulham Road, London SW3 6JB, UK. (2)
1Arkana Laboratories, 10810 Executive Center Drive #100, Little Rock, AR 72211 (1)
2Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Madison, WI 53705, USA (1)
Analytical Chemistry Core Lab (ACL) – Proteomics Unit Building 2 east, Level 2, 2281-WS05 King Abdullah University of Science and Technology (KAUST) Thuwal, 23955-6900, Kingdom of Saudi Arabia (1)
Arkana Laboratories, 10810 Executive Center Drive #100, Little Rock, AR 72211 (1)
Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA (1)
Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands (1)
Biomolecular Mass Spectrometry and Proteomics Group, Utrecht University (1)
Center for Applied and Translational Genomics, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates (1)
Center for Genomics and Systems Biology, New York University, New York, NY, US (1)
Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet SE 17177 Stockholm, Sweden. Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, 119146, Russia. (1)
Dartmouth College (1)
Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205 Arkansas Children's Research Institute, Little Rock, AR (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA (1)
Department of Neurobiology and Developmental Science, University of Arkansas for Medical Sciences, Little Rock, AR (1)
Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA. (1)
Department of Urology, Radboud Institute for Medical Innovation, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands. (1)
Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, The United Kingdom. (1)
Division of Cell Matrix Biology & Regenerative Medicine (L5) / Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester (1)
IUSM Center for Proteome Analysis, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN (1)
Immunopathology of Virus Infections Institute of Virology Technical University of Munich Munich, Germany (1)
Laboratory of Pediatrics, Section Systems Medicine of Metabolism and Signaling, Faculty of Medical Sciences, University of Groningen, University Medical Center Groningen, Groningen,the Netherlands (1)
Novo Nordisk Foundation Center for Protein Research, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (1)
Professor in molecular biology and scientific leader of PROMEC Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences +4773598608 +4791825455 +4772573076 Laboratoriesenteret, 231.05.034, Øya, Erling Skjalgssons g 1 Trondheim 7030, Norway (1)
Proteomics, Institute of Theoretical Medicine, University of Augsburg, 86159 Augsburg, Germany (1)
School of Life and Environmental Sciences, Charles Perkins Centre, Faculty of Science, The University of Sydney, NSW, Australia. (1)
School of Optometry, the Hong Kong Polytechnic University, Hong Kong, China Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China Research Centre for SHARP Vision (RCSV), the Hong Kong Polytechnic University, Hong Kong, China Research Centre for Chinese Medicine (RCMI), the Hong Kong Polytechnic University, Hong Kong, China (1)
UCSD (1)

Previous page
1 / 503
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 503
Next page

Sort by:

Relevance

Page size

Proteomic Analysis of ROCK Inhibitor-treated ARPE-19 Cells

Rho-associated protein kinase (ROCK) inhibitors are highly present in different ocular tissues, and upregulation of ROCK pathway has been shown related to the pathogenesis of multiple ocular disorders, including glaucoma, diabetic retinopathy and age-related macular degeneration (AMD). However, the ...

ORGANISM(S): Homo sapiens (Human)

2024-12-04 | PXD051479 | Pride

Effect of ROCK Inhibitor on myeloid cells during GvHD

PRJNA952633 | ENA

Melanoma NRAS - Cooperative induction of apoptosis in nras mutant melanoma by inhibition of mek and rock

In the present work we propose a new therapy for NRAS mutant melanoma. Simultaneous inhibition of MEK and ROCK caused induction of BimEL , PARP, and Puma, and hence apoptosis. In vivo, MEK and ROCK inhibition suppressed growth of established tumors. Our findings warrant clinical investigation of the...

ORGANISM(S): Homo sapiens (Human)

2015-03-11 | PXD000528 | Pride

Phosphoproteome Melanoma Wholeproteome Nras

Effect of ROCK Inhibitor on myeloid cells during GvHD

GvHD mice (allo transplant) and treated mice with ROCK Inhibitor 8mg /kg or PBS (vehicle)

ORGANISM(S): Mus musculus

2023-12-04 | GSE229043 | GEO

Immortalization and characterization of rat lingual keratinocytes in a high-calcium and feeder-free culture system using ROCK inhibitor Y-27632

The study tried the identify some differentially expressed proteins in rat lingual keratinocytes treated with or without the ROCK inhibitor Y-27632. In brief, rat lingual keratinocytes were treated with or without Y-27632 for 36 h and were subjected to proteomic analysis.

ORGANISM(S): Cellular Organisms

2022-06-23 | PXD025812 | JPOST Repository

Reduced expression of RhoE promotes ROCK-dependent invasion in transformed human fibroblasts

Cen3tel cells, obtained by telomerase immortalization of human fibroblasts, gradually underwent neoplastic transformation and became metastatic in immunocompromised mice. Neoplastic transformation was associated with a change in cell morphology (from fibroblastic to polygonal). Tumorigenic cells acq...

ORGANISM(S): Homo sapiens

2011-04-20 | E-GEOD-15742 | biostudies-arrayexpress

Gene expression profiles in colon cancer spheroids treated with a ROCK inhibitor

PRJNA482364 | ENA

Gene expression profiles in colon cancer spheroids treated with a ROCK inhibitor

Spheroid cells derived from colon cancer patients was treated with Y-27632, a ROCK inhibitor, and we have performed whole genome microarray expression assay.

ORGANISM(S): Homo sapiens

2021-04-01 | GSE117505 | GEO

Pyrosequencing Analysis of Microbial Communities in Rock Varnish

This study investigated the microbial community of rock varnish Based on consensus sequences for 16S OTUs

ORGANISM(S): uncultured prokaryote

2013-04-26 | E-GEOD-46347 | biostudies-arrayexpress

Impairment of autophagic flux by combined EGFR and ROCK inhibition leads to triple-negative breast cancer cell death

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with very limited therapeutic options. We have recently shown that the combined inhibition of EGFR and ROCK in TNBC cells results in cell cycle arrest and ultimately cell death. However, the underlying mechanisms by which...

ORGANISM(S): Homo sapiens (Human)

2019-12-04 | PXD013821 | Pride

Autophagy Triple-negative breast cancer Proteomics Label-free Rock Targeted therapy Egfr

Previous page
1 / 503
You're on page 1
page 2
page 3
page 4
page 5
page ...
page 503
Next page

Sort by:

Relevance

Page size

5023 Results

Show results for

Organisms

Organisms

Repository

Tissue

Disease

Technology Type

Instrument Platform

Publication Date

CHEBI ID

Metabolite Name

First Public Date

Classification

Study type

Release Date

Lab affiliation

Tags

OmicsDI is part of the ELIXIR infrastructure

Tweets