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TranscriptomicsTranscription profiling of S. cerevisiae (budding yeast) mutants reveals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death
Changes in the transcriptome of Isc1p deficient mutants. The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resis...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-05 | E-MEXP-1136 | biostudies-arrayexpress
ProteomicsMebendazole Inhibits Histoplasma capsulatum In Vitro Growth and Decreases Mitochondrion and Cytoskeleton Protein Levels
Histoplasmosis is a frequent mycosis in people living with HIV/AIDS and other immunocompromised hosts. Histoplasmosis has high rates of mortality in these patients if treatment is unsuccessful. Itraconazole and amphotericin B are used to treat histoplasmosis; however, both antifungals have potential...
ORGANISM(S): Fungi Histoplasma capsulatum 
2023-03-22 | PXD033762 | Pride
Histoplasma capsulatum  mebendazole  drug repositioning. antifungal activity Proteomic analysis 
ProteomicsProteomic profile of healthy human monocytes differentiated to macrophages with non-tumor or tumor cell-derived extracellular vesicles
To investigate the impact of tumor cell-derived extracellular vesicles on monocyte-macrophage differentiation, healthy monocytes were treated with EVs derived from two different pancreatic cancer cell lines and a non-tumoral pancreatic ductal epithelial cell line. Following differentiation to macrop...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD039439 | Pride
Lc-msms Monocytes Tumor-associated macrophages Extracellular vesicles Immunosuppression 
UnknownOptical Memory in a MoSe<sub>2</sub>/Clinochlore Device.
Not available
S-EPMC11874464 | biostudies-literature
ProteomicsThe impact of tumor cell-derived extracellular vesicles on primary PDAC cancer-associated fibroblast matrisomes
To investigate the impact of tumor-cell derived extracellular vesicles (EVs) on cancer-associated fibroblasts (CAFs) secretory phenotypes, CAFs were treated with pancreatic cancer cell line-derived EVs and produced extracellular matrices (ECM). ECMs denuded of cells were analyzed by mass spectrometr...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD039279 | Pride
Lc-msms Extracellular vesicles Matrisome Extracellular matrix Pdac 
UnknownIdentification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer.
Not available
S-EPMC8026514 | biostudies-literature
UnknownA reference genome for common bean and genome-wide analysis of dual domestications.
Not available
S-EPMC7048698 | biostudies-literature
UnknownConstructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Not available
S-EPMC9417284 | biostudies-literature
UnknownPhenotype harmonization and analysis for The Populations Underrepresented in Mental illness Association Studies (the PUMAS Project).
Not available
S-EPMC11537327 | biostudies-literature
UnknownEffect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
Not available
S-EPMC6542461 | biostudies-literature
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