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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
ProteomicsIn Cellulo Kinase Screen Identifies Novel MASTL Substrates
MASTL (microtubule-associated serine/threonine kinase-like) has emerged as a critical regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp-19/ENSA are the only known substrates of MASTL. With the cellular roles of MASTL expanding and increased interest in deve...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD028678 | Pride
Akt Phospho-peptides Silac Agc kinase Kinase Mastl 
TranscriptomicseQTL mapping in Lake Whitefish Species Pairs.
Mapping of expression quantitative trait loci (eQTL) is a powerful means for elucidating the genetic architecture of gene regulation. Yet, eQTL mapping has not been applied towards investigating the regulation architecture of genes involved in the process of population divergence, ultimately leading...
ORGANISM(S): Coregonus clupeaformis 
2008-09-01 | E-GEOD-11378 | biostudies-arrayexpress
UnknownThe Molecular Link Between TDP-43, Endogenous Retroviruses and Inflammatory Neurodegeneration in Amyotrophic Lateral Sclerosis: a Potential Target for Triumeq, an Antiretroviral Therapy.
Not available
S-EPMC10533598 | biostudies-literature
ProteomicsGlobal phosphoproteomic mapping of early mitotic exit in human cells identifies novel substrate dephosphorylation motifs
Entry into mitosis is driven by the coordinated phosphorylation of thousands of proteins. For the cell to complete mitosis and divide into two identical daughter cells it must regulate dephosphorylation of these proteins in a highly ordered, temporal manner. There is currently a lack of a complete u...
ORGANISM(S): Homo sapiens (Human) 
2015-06-25 | PXD001559 | Pride
Motif Spindle assembly checkpoint. Mitosis Phosphatase Silac Prc1 Myc Phosphorylation Mitotic exit Kinase Phosphoproteomics 
no omics definedTranscription profiling of multiple karp tissues under cold acclimation treatments
To screen for genes involved in cold-acclimation in carp
ORGANISM(S): Cyprinus carpio 
2005-11-09 | E-MAXD-1 | biostudies-arrayexpress
TranscriptomicsThe hibernating phenotype assessed through transcript screening
Mammalian hibernation is a dramatic physiological transition that involves the controlled reduction of regulated body temperature and the consequent depression of all physiological processes. The resulting reduction of metabolism and associated energy expenditure permits survival during extended pe...
ORGANISM(S): Spermophilus lateralis 
2010-06-05 | E-GEOD-2033 | biostudies-arrayexpress
TranscriptomicsBrain eQTL analysis of lake whitefish species-pairs (Coregonus sp.)
We used microarrays and a previously established linkage map to localize the genetic determinants of brain gene expression for a backcross family of lake whitefish species pairs (Coregonus sp.). Our goals were to elucidate the genomic distribution and sex-specificity of brain expression QTL (eQTL) ...
ORGANISM(S): Coregonus clupeaformis 
2008-09-01 | E-GEOD-12068 | biostudies-arrayexpress
UnknownProbing single-cell oxygen reserve in sickled erythrocytes via in vivo photoacoustic microscopy.
Not available
S-EPMC8671229 | biostudies-literature
ProteomicsHs_MitoticExit_Phos_Silac_IT
Global phosphoproteomic mapping of early mitotic exit in human hela cells, ITCID
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005294 | PeptideAtlas
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