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ProteomicsMulti-omics profiling of lung samples from genetically diabetic pigs reveals reduced ALOX15 expression and impaired eicosanoid switching as mechanisms contributing to a proinflammatory milieu
To evaluate molecular consequences of insulin-deficient diabetes mellitus for lung tissue, we used clinically diabetic pig model of mutant INS gene induced diabetes of youth (MIDY). A multi-omics analysis combining in-depth data-independent acquisition proteomics, and targeted lipidomics revealed mu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-07-01 | PXD038014 | Pride
Lipoxygenase Lung Lipidome Diabetes Biobank Insulin deficiency Pig model Proteome 
ProteomicsProteomic analysis of liver tissue from a pig model of mutant INS gene induced diabetes of youth (MIDY)
To evaluate functional consequences of insulin-deficient diabetes mellitus for the liver, we used a genetically engineered pig model of mutant INS gene induced diabetes of youth (MIDY). Liver samples of MIDY pigs and wild-type (WT) littermate controls were analyzed by label-free proteomics to reveal...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2019-11-12 | PXD011536 | Pride
Animal model Biobank Midy Pig model Diabetes Liver Lc-ms/ms 
UnknownArrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.
Not available
S-EPMC4836279 | biostudies-literature
UnknownPharmacological and pre-clinical safety profile of rSIV.F/HN, a hybrid lentiviral vector for cystic fibrosis gene therapy.
Not available
S-EPMC11780724 | biostudies-literature
UnknownTowards high-resolution laser ionization spectroscopy of the heaviest elements in supersonic gas jet expansion.
Not available
S-EPMC5322538 | biostudies-literature
UnknownPathogenicity of missense variants affecting the collagen IV α5 carboxy non-collagenous domain in X-linked Alport syndrome.
Not available
S-EPMC9253329 | biostudies-literature
UnknownTechnical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometry.
Not available
S-EPMC12330888 | biostudies-literature
UnknownGenotype-phenotype correlations for COL4A3-COL4A5 variants resulting in Gly substitutions in Alport syndrome.
Not available
S-EPMC8854626 | biostudies-literature
UnknownImproved survival with vemurafenib in melanoma with BRAF V600E mutation.
Not available
S-EPMC3549296 | biostudies-literature
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