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MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
TranscriptomicsLMP2A mediated gene expression changes in transfected CD10+ GCB cells
In this study, we have investigated the effect of LMP2A on gene expression in normal human GC B cells using a non-viral vector based system Keywords: transfection of viral oncogene in normal human B cells Gene expression was compared between LMP2A-transfected and control vector-transfected GC B cell...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-46143 | biostudies-arrayexpress
TranscriptomicsDown-regulation of BLIMP1-alpha by the EBV oncogene, LMP1, disrupts the plasma cell differentiation program and prevents viral replication in B cells
In this study, we have investigated the effect of BLIMP1α on gene expression, cell differentiation and pathogenesis in normal human GC B cells using a non-viral vector based system Gene expression was compared among BLIMP1α, LMP1-transfected and control vector-transfected GC B cells from two patient...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-27670 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis identifies a subset of Group A var genes that encode the malaria parasite ligands for binding to human brain endothelial cells
Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterised by the accumulation of infected erythrocytes in the microvasculature of the brain, due to parasite adhesins on the surface of infected erythrocytes binding to...
ORGANISM(S): Plasmodium falciparum 
2011-11-01 | E-GEOD-32211 | biostudies-arrayexpress
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
ProteomicsHigh mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria
In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans, expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD20...
ORGANISM(S): Homo sapiens (Human) 
2021-03-17 | PXD024022 | Pride
Red blood cells Sickle cells Malaria 
UnknownRed blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance.
Not available
S-EPMC7979802 | biostudies-literature
UnknownMajor Urological Cancer Surgery for Patients is Safe and Surgical Training Should Be Encouraged During the COVID-19 Pandemic: A Multicentre Analysis of 30-day Outcomes.
Not available
S-EPMC7796655 | biostudies-literature
UnknownCampath, calcineurin inhibitor reduction and chronic allograft nephropathy (3C) study: background, rationale, and study protocol.
Not available
S-EPMC3674985 | biostudies-literature
UnknownLong- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.
Not available
S-EPMC6001640 | biostudies-literature
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