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ProteomicsPhosphorylation of CPSF6 RS-like domain
Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor CPSF6, regulates alternative polyadenylation (APA). CPSF6 has a RS-like domain which plays role in protein -protein interactions. This interaction might have role in alternative polyadenylation s...
ORGANISM(S): Homo sapiens (Human) 
2019-04-01 | PXD012713 | Pride
Cfim68 Cpsf6 Rs domain Rs-like domain Apa 
GenomicsCoccidioides immitis RS strain:RS
WGS sequencing, assembly, and annotation
PRJNA12883 | ENA
MetabolomicsThe novel protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment
Metabolic reprogramming fuels cancer cell metastasis and remodels the immunosuppressive tumor microenvironment (TME). We report here that a circRNA, circPETH, packaged by extracellular vesicles (EVs) from tumor-associated macrophages (TAMs) to hepatocellular carcinoma (HCC) cells, facilitates glycol...
2024-12-09 | MTBLS11254 | MetaboLights
ProteomicsU2AF2 controls alternative splicing in speckles proximal regions in an RS domain-dependent manner
Splicing factor U2AF2 is known to play a pivotal role for 3' splice site recognition at an early step of spliceosome assembly. Here using proximity labeling and biochemical confirmations, we extend the repertoire of putative functional partners of U2AF2 mainly for splicing, chromatin modification, t...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD065448 | Pride
U2af2/ rs domain/ alternative splicing/ nuclear sepckles/ phosphorylation 
TranscriptomicsTranscriptional regulation in pluripotent stem cells by Methyl CpG binding protein 2 (MeCP2)
Rett syndrome (RTT) is one of the most prevalent female mental disorders. De novo mutations in methyl CpG binding protein 2 (MeCP2) are a major cause of RTT. MeCP2 regulates gene expression as a transcription regulator as well as through long-range chromatin interaction. Because MeCP2 is present on ...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51607 | biostudies-arrayexpress
TranscriptomicsProtein P Vs Protein G
Rationale: Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Co-infection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear. Objectives: To determine if interaction between RS...
ORGANISM(S): Streptococcus pneumoniae D39 
2014-06-21 | E-GEOD-58424 | biostudies-arrayexpress
ProteomicsHyperosmolarity adversely impacts heterologous secretory protein synthesis by Yarrowia lipolytica
In this research we were interested in answering a question whether subjecting Y. lipolytica strain overproducing recombinant secretory protein (rs-Prot) to a specific, pre-optimized stress factor may enhance synthesis of the target macromolecule. Increased osmolarity (3 Osm/kg) was the primary stre...
ORGANISM(S): Yarrowia Lipolytica (ncbitaxon:4952) 
2021-10-13 | MSV000088228 | MassIVE
ProteomicsmTOR inhibition ameliorates tau burden and neurofilament pathology in sporadic PSP-RS neurons
Progressive supranuclear palsy, Richardson’s syndrome subtype (PSP-RS), is a tauopathy marked by early axonal pathology and neurodegeneration. Modeling sporadic PSP-RS in human neurons remained a major challenge. Here, we generated midbrain dopaminergic (mDA) neurons from induced pluripotent stem ce...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD072104 | Pride
Tauopathy  progressive supranuclear palsy  neurofilament  dopaminergic neurons  axonal degeneration  autophagy modulation 
TranscriptomicsTranscriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles part 2
To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (90M-BM- ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45868 | biostudies-arrayexpress
TranscriptomicsTranscriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles part 1
To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (50M-BM- ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45598 | biostudies-arrayexpress
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