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TranscriptomicsRNA-seq of rs2280381-containing region knock out clone in U937
rs2280381 is an autoimmune disease susceptible loci, which have be reported to be associated with SLE, RA and SSc.Genetic and epigenomic analysis indicate that rs2280381-containing region is an enhancer region in monocyte. To test the function and regulated genes of rs228381-containing region, we de...
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-10126 | biostudies-arrayexpress
TranscriptomicsRNA-seq data of rs2280381-containing region knock out clone in U-937 cell line
rs2280381 is an autoimmune disease susceptible variant, which has been reported to be associated with SLE, RA and SSc. Genetic and epigenomic analysis indicate that the rs2280381-containing region is an enhancer region in monocyte. To test the function and regulated genes of the rs228381-containing ...
ORGANISM(S): Homo sapiens 
2022-02-25 | E-MTAB-11306 | biostudies-arrayexpress
GenomicsRNA-seq of rs2280381-containing region knock out clone in U937
RNA-seq of rs2280381-containing region knock out clone in U937
PRJEB43182 | ENA
Proteomicsidentify the possible proteins that specifically bind to the 59-bp nucleotide sequence containing rs2280381
we performed DNA-affinity precipitation assay (DAPA) followed by mass spectrometry to identify the possible proteins that specifically bind to the 59-bp nucleotide sequence containing rs2280381 using U-937 cell nuclear extracts.
ORGANISM(S): Homo sapiens (Human) 
2022-02-26 | PXD029688 | Pride
Ms Rs2280381 Dapa Human 
Genomics4C-Seq identify the interaction between IRF8 promoter and rs2280381-containing region
4C-Seq identify the interaction between IRF8 promoter and rs2280381-containing region
PRJEB43169 | ENA
Transcriptomics4C-Seq identify the interaction between IRF8 promoter and rs2280381-containing region
To test if there is a physical interaction between the IRF8 promoter and the rs2280381-containing region, we conducted circular chromatin conformation capture assay in the U937 cell. For the IRF8 viewpoint group, we used CSP6I as the first digested enzyme and NlaIII as the second enzyme. For the r...
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-10120 | biostudies-arrayexpress
GenomicsRNA-seq data of rs2280381-containing region knock out clone in U-937 cell line
RNA-seq data of rs2280381-containing region knock out clone in U-937 cell line
PRJEB50025 | ENA
Genomics4C-Seq identify the interaction between IRF8 promoter and rs2280381-containing region in human primary monocyte
4C-Seq identify the interaction between IRF8 promoter and rs2280381-containing region in human primary monocyte
PRJEB48918 | ENA
Transcriptomics4C-Seq identify the interaction between IRF8 promoter and rs2280381-containing region in human primary monocyte
To test if lncRNA AC092723.1 play a role in physical interaction between the IRF8 promoter and the rs2280381-containing region, we conducted circular chromatin conformation capture assay in the human primary monocyte. We knock down lncRNA AC092723.1 by electro-transfecting ASOs, the control group is...
ORGANISM(S): Homo sapiens 
2022-02-25 | E-MTAB-11175 | biostudies-arrayexpress
UnknownLupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery.
Not available
S-EPMC8987079 | biostudies-literature
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