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TranscriptomicsEndogenous shRNAs, siRNAs, and Other Microprocessor-independent, Dicer-dependent Small RNAs in Mouse ES Cells
Canonical microRNAs (miRNAs) require two processing steps: the first by the Microprocessor, a complex of DGCR8 and Drosha, and the second by Dicer. dgcr8delta/delta mouse embryonic stem cells (mESCs) have less severe phenotypes than dicer1delta/delta mESCs, suggesting a physiological role for Microp...
ORGANISM(S): Mus musculus 
2008-09-09 | E-GEOD-12521 | biostudies-arrayexpress
ProteomicsSOX4 AND SMARCA4 COOPERATIVELY REGULATE PI3K SIGNALING THROUGH TRANSCRIPTIONAL ACTIVATION OF TGFBR2 IN BASAL LIKE BREAST CANCER
Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate that the transcription factor SOX4 is a key regulator of PI3K...
ORGANISM(S): Homo sapiens (Human) 
2021-03-02 | PXD022811 | Pride
Breast cancer Smarca4 Transcription Epigenetics Tgfbr2 Swi/snf Pi3 kinase Sox4 Chromatin 
MetabolomicsRANCM: a new ranking scheme for assigning confidence levels to metabolite assignments in NMR-based metabolomics studies

INTRODUCTION: The Metabolomics Standards Initiative has recommended four categories for metabolite assignments in NMR-based metabolic profiling studies. The putatively annotated compound category is most commonly reported by metabolomics investigators. However, there is significa...

2019-09-27 | MTBLS781 | MetaboLights
GenomicsG&T-seq: parallel sequencing of the genomes and transcriptomes of single cells
The ability to simultaneously sequence the genome and transcriptome of the same single cell offers a powerful means to dissect functional genetic heterogeneity at the cellular level. Here we describe G&T-seq, a method for separating and sequencing genomic DNA and full-length mRNA from single cells. ...
EGAS00001001204 | EGA
GenomicsEGAS00001001204-sc-20150415 - samples
Development of a method for separation and parallel sequencing of the genomes and transcriptomes of single cells.
EGAD00001001332 | EGA
GenomicNEI Age-Related Eye Disease Study (AREDS)

The Age-Related Eye Disease Study (AREDS) was initially designed as a long-term multi-center, prospective study of the clinical course of age-related macular degeneration (AMD) and age-related cataract. In addition to collecting natural history data, AREDS included a clinical trial of high-dose ...

phs000001 | dbGaP
UnknownAn Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes
Not available
S-SCDT-10_1038-S44319-025-00620-4 | biostudies-other
UnknownGenomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency.
Not available
S-EPMC8799468 | biostudies-literature
UnknownSubretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.
Not available
S-EPMC4549177 | biostudies-literature
UnknownPredominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials.
Not available
S-EPMC10282893 | biostudies-literature
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