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ProteomicsLztr1 loss leads to Noonan syndrome-like vascular defects by dysregulating vesicular trafficking
Mutations in LZTR1, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, are associated with glioma, hepatocarcinoma, paediatric cancers, Schwannomatosis, and Noonan syndrome (NS). NS is a poorly understood and complex disease. The variety of NS phenotypes makes it challenging to elucidate the m...
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD011926 | Pride
Hela cells Vegf Noonan syndrome Lztr1 Vesicular trafficking Ubiquitin Chmp1b 
ProteomicsLoss-of-function of ubiquitin ligase adaptor LZTR1 triggers human disease by dysregulating RAS ubiquitination
Mutations in LZTR1, a substrate adaptor for cullin 3 (CUL3) ubiquitin ligase complexes, have been recently associated with Noonan syndrome and familial Schwannomatosis. Concordantly, we found that Lztr1+/- mice showed craniofacial abnormalities, cardio defects, and premature ageing; whereas loss of ...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-07 | PXD007035 | Pride
Ras signalling Schwannomatosis Noonan syndrome Ubiquitin 
ProteomicsStress-induced lncRNA LAS3 fosters fitness of cancer cells by regulating SART3-mediated spliceosome recycling
Long non-coding RNAs (lncRNAs) represent a novel class of anti-cancer therapeutic targets. Hypoxia-induced lncRNAs are associated with the aggressive tumor phenotypes and might serve as putative drug targets. Here, we unraveled lncRNAs whose expression is upregulated in hypoxic breast tumors. One of...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD013334 | Pride
Breast cancer Hypoxia Sart3 Intron retention Long non-coding rnas 
ProteomicsProfiling of Proteome and Ubiquitome Changesin in endothelial cells in response to shear stress
Shear stress generated by flowing blood has major effects on vascular function. Bends and branches of arteries are exposed to complex blood flow patterns, a mechanical environment that promotes cardiovascular dysfunction and atherosclerosis. The exact mechanisms, by which endothelial cells translate...
ORGANISM(S): Homo sapiens (Human) 
2025-05-23 | PXD024309 | Pride
Endothelial cells Ubiquitome Shear stress Proteome 
ProteomicsMutations in TRAF7 drive meningioma development by dysregulating proteostasis of the RAS-like GTPases
Meningiomas are the most common primary brain tumors, where complete surgical resection is often challenging giving rise to recurrence. Mutations of the E3 ubiquitin ligase TRAF7 are found in one-fourth of meningioma patients and typically co-occur with mutations in either KLF4, AKT1, or PI3KCA. By ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-19 | PXD021188 | Pride
Meningioma Cancer Multi-omics Actin cytoskeleton Ras pathway Semaphorin pathway Proteostasis 
ProteomicsDysregulation of RAS degradation limits the efficacy of RAS inhibitors via reprogramming amino acid sensing machinery
To investigate the molecular consequences of LZTR1 loss and its impact on KRAS-regulated signaling, we performed deep proteomic and phosphoproteomic profiling using mass spectrometry. Human tumor cells with CRISPR/Cas9-mediated LZTR1 knockout and their isogenic controls were subjected to tandem mass...
ORGANISM(S): Homo sapiens (Human) 
2025-10-09 | PXD063962 | Pride
Mtor Luad Kras 
UnknownK128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
Not available
S-SCDT-10_1038-S44318-024-00146-W | biostudies-other
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