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MetabolomicsGut microbiota-derived butyric acid protected against secondary brain injury after SAH by inhibiting neuronal pyroptosis and regulating gut microbiota composition (Human assays)

BACKGROUND: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease with a poor prognosis. Accumulating studies have reported that gut microbiota contributes to the pathophysiology of several central nervous system diseases. However, whether SAH can change gut micr...

2024-07-09 | MTBLS9087 | MetaboLights
TranscriptomicsTranscription profiling of rat cerebral arteries from rats after experimental SAH with the expression in cerebral vessels from sham operated animals
We have compared the gene-expression in cerebral arteries from rats after experimental SAH with the expression in cerebral vessels from sham operated animals. The model is well characterised (Prunell et al. 2003; Prunell et al. 2004) regarding the physiological changes but not regarding the gene exp...
ORGANISM(S): Rattus norvegicus 
2006-01-01 | E-MEXP-338 | biostudies-arrayexpress
ProteomicsA patient-based Drosophila model for mitochondrial S-Adenosylhomocysteine transport deficiency
The SLC25A26 gene encodes a mitochondrial inner membrane carrier that transports S-adenosylmethionine (SAM) into the mitochondrial matrix in exchange for S-adenosylhomocysteine (SAH). SAM is the predominant methyl-group donor for most cellular methylation processes, of which SAH is produced as a by-...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-01-19 | PXD026900 | Pride
Sam Samc Methylation Sah Mitochondria Drosophila Slc25a26 
ProteomicsInhibition of Ubiquitin Thioester Transfer by Targeting a Helix-in-Groove Interaction between E1 and E2
In eukaryotes, E1 initiates the ubiquitin cascade by adenylation and thioesterification of the ubiquitin C-terminus and subsequent transfer of ubiquitin to E2 enzymes. A clinical-grade small molecule that binds to the E1 ATP binding site and covalently derivatizes the ubiquitin C-terminus effectivel...
ORGANISM(S): Homo sapiens (Human) 
2020-08-18 | PXD016014 | Pride
Protein degradation Hdxms Conformational change Hydrogen deuterium exchange Ubiquitin ligase 
TranscriptomicsTargeted disruption of the BCL9/beta-catenin complex in cancer
Stabilized Alpha-Helix peptides of BCL9 HD2 (SAH-BCL9) block BCL9 and B9L interactions with beta-catenin and specifically downregulate Wnt target gene expression. RNA from triplicate SAH-BCL9B- and vehicle-treated DLD1 samples (10 µM each for 12 hours) was hybridized to Affymetrix Human U133 Plus 2....
ORGANISM(S): Homo sapiens 
2012-08-23 | E-GEOD-33143 | biostudies-arrayexpress
UnknownPrediction of Outcome Using Quantified Blood Volume in Aneurysmal SAH.
Not available
S-EPMC7342737 | biostudies-literature
UnknownThe protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage.
Not available
S-EPMC9392539 | biostudies-literature
UnknownCrystal structure and ligand-induced folding of the SAM/SAH riboswitch.
Not available
S-EPMC7367207 | biostudies-literature
ProteomicsFishing for SAM/SAH-binding proteins
The aim of the project was to identify S-adenodsyl methionine-binding proteins expressed in D. melanogaster S2 cells. For this puprose a capture compund reagent carrying a SAH-affinity group, a biotin group for enrichment and a cross-linking moiety consisting of either benzophenone or a nitrobenzen...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-02-25 | PXD006245 | Pride
Capture compound S-adenosyl-methionine Lysine methylation Methyltransferase 
UnknownAutophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH.
Not available
S-EPMC8447596 | biostudies-literature
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