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ProteomicsActivity based proteome profiling of serum serine hydrolases: application in pediatric abusive head trauma
Purpose: Traumatic brain injury (TBI), including pediatric abusive head trauma (AHT), is the leading cause of death and disability in children and young adults worldwide. The current understanding of trauma-induced molecular changes in the brain of human subjects with intracranial haemorrhage (ICH) ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-26 | PXD057319 | Pride
Human Serum Activity based proteome profilling 
ProteomicsIdentification of functional miRNA gene interactions in mESC by computational data integration approaches.
miRNAs are short regulatory single stranded RNA sequences that upon complementary binding to mRNAs lead to the inhibition or degradation of their targets. This regulatory mechanisms has been shown to play crucial roles throughout the whole life cycle of animals and plants as well as in disease. Whil...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-31 | PXD014484 | Pride
Mouse Mass spectrometry Data integration Proteomics Mirna Ribosome profiling Stem cells Transcriptomics 
ProteomicsA technique to identify context-based protein biomarkers: Application to a mouse liver cancer model
To date, most proteomic analyses towards cancer biomarker discovery have been based on protein quantification. However, proteins function in association with other proteins to form modules that are localized in specific subcellular compartments. Cellular mislocalization of proteins has in fact been...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD008758 | Pride
Cancer Mouse liver Swath-ms 
ProteomicsA new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model (validation part)
To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules localized in particular subcellular compartment...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD013295 | Pride
Mouse Cancer Biomarker Liver 
ProteomicsActivity-based SWATH/DIA proteomic screen enables sensitive differential detection of serine hydrolases from surgically resected OCT-embedded primary lung adenocarcinoma
Lung malignancies are among the leading causes of cancer-related death in the modern world. While the disease is relatively manageable if caught at an early stage, the genomic variability and high level of mutations represent a daunting challenge for diagnosis, staging and prognostic classification....
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD019357 | Pride
Abpp Lung adenocarcinoma tissue Swath-ms 
ProteomicsDetection of Five Solid Carcinomas Using Blood Circulating Proteins
When diagnosed in a metastatic stage cancer is mostly incurable making its early detection via biomarkers of immense clinical interest. Proteins circulating in blood are a preferred source of biomarkers for a wide range of cancers due to the ease and non-invasiveness of collection. Our approach to c...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD004998 | Pride
N-glycoprotein Biomarker Swath-ms Plasma 
ProteomicsIdentification of novel blood protein biomarkers in infants with Acute Intracranial Hemorrhage
Abusive head trauma (AHT) is a leading cause of mortality and morbidity in infants. We explored novel AHT biomarkers via untargeted proteomics of peripheral postmortem blood (PMB) specimens collected during medico-legal autopsies of infants. The panel of PMB biomarkers was confirmed in antemortem se...
ORGANISM(S): Homo sapiens (Human) 
2023-01-07 | PXD028801 | Pride
Dia-ms Postmortem blood proteomics 
ProteomicsSMYD3: a new regulator of the early steps of adipocyte differentiation
Abstract Background In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The individual ability to tip the balance toward the hyperplastic growth, with recruitment of new fat cells through adipogenesis, seems to ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-03 | PXD043165 | Pride
Adipose tissue Mice 
MetabolomicsCadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes
Obesity is considered as a major public health concern with strong economic and social burdens. Exposure to pollutants such as heavy metals can contribute to the development of obesity and its associated metabolic disorders, including type 2 diabetes and cardiovascular diseases. Adipose tissue is an...
2023-06-29 | MTBLS4128 | MetaboLights
MetabolomicsArsenic induces metabolome remodeling in mature human adipocytes
Human lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the deve...
2025-05-23 | MTBLS8808 | MetaboLights
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