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TranscriptomicsSalvelinus Microarray experiment: selected line vs control line
Domestication has been practiced for centuries yet directed towards relatively few terrestrial crops and animals. While phenotypic and quantitative genetic changes associated with domestication have been amply documented, little is known about the molecular changes underlying the phenotypic evolutio...
ORGANISM(S): Salvelinus fontinalis 
2010-06-24 | E-GEOD-20490 | biostudies-arrayexpress
TranscriptomicsAtlantic salmon (Salmo salar) liver transcriptome response to diets containing camelina products
This study was performed to investigate assess the impacts of CO and/or CM containing diets on Atlantic salmon hepatic gene expression in order to identify candidate molecular biomarkers of responses to camelina-containing diets. Atlantic salmon were fed diets with complete or partial replacement of...
ORGANISM(S): Salmo salar 
2015-05-12 | E-GEOD-56784 | biostudies-arrayexpress
TranscriptomicsA toolbox for epitope-tagging and genome-wide location analysis in Candida albicans
Background : Candida albicans is a diploid pathogenic fungus not yet amenable to routine genetic investigations. Understanding aspects of the regulation of its biological functions and the assembly of its protein complexes would lead to further insight into the biology of this common disease-causing...
ORGANISM(S): Candida albicans 
2010-05-16 | E-GEOD-13427 | biostudies-arrayexpress
TranscriptomicsExperimental annotation of the human pathogen Candida albicans coding and noncoding transcribed regions using high resolution tiling arrays
Compared to other model organisms and despite the clinical relevance of the pathogenic yeast Candida albicans, no comprehensive analysis has been done to provide experimental support of its in silico-based genome annotation. Here we have undertaken a genome-wide experimental annotation to accurately...
ORGANISM(S): Candida albicans 
2010-07-07 | E-GEOD-22625 | biostudies-arrayexpress
TranscriptomicsRNA-seq of splenic follicular B cells from wild-type and IKZF1 L132P mutant mice
Comparing the effect of the L132P variant in ZF1 of IKZF1 on the gene expression in sorted follicular B cells.
ORGANISM(S): Mus musculus 
2021-01-29 | E-MTAB-9975 | biostudies-arrayexpress
ProteomicsMapping in silico genetic networks of tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Cancers harbouring loss-of-function (LOF) alterations in tumour suppressor genes lack targeted therapies, thus alternative means to characterise gene function and identify vulnerabilities in these cancer cells are required. Here, we map the in silico genetic networks of KMT2D, a frequently mutated t...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD048272 | Pride
Metabolism Kmt2d Immune checkpoint inhibitor Genetic networks Synthetic lethality 
TranscriptomicsThe zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion
Biofilm development by Candida albicans requires cell adhesion for the initial establishment of the biofilm and the continued stability after hyphal development occurs; however, the regulation of the process has not been fully established. Using chromatin immunoprecipitation coupled to microarray an...
ORGANISM(S): Candida albicans 
2010-11-10 | E-GEOD-25174 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of synovial tissue biopsies from individuals with rheumatoid arthritis from the STRAP randomised clinical trial
Transcriptomic profiles of synovial biopsies of rheumatoid arthritis (RA) patients recruited into the STRAP randomised clinical trial: RNA-Seq data from 210 patients at baseline. Patients were randomly assigned to etanercept, tocilizumab and rituximab. For the full study protocol and baseline patien...
ORGANISM(S): Homo sapiens 
2025-04-28 | E-MTAB-13733 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of synovial tissue biopsies from individuals with rheumatoid arthritis from the R4RA randomised clinical trial
Transcriptomic profiles of synovial biopsies of rheumatoid arthritis (RA) patients who were recruited into the R4RA randomised clinical trial. Patients were randomised to treatment with rituximab or tocilizumab. All patients fulfilled the 2010 ACR/EULAR classification criteria for RA and were eligib...
ORGANISM(S): Homo sapiens 
2022-04-26 | E-MTAB-11611 | biostudies-arrayexpress
TranscriptomicsPoly(A)-Specifc Ribonuclease 1 (PARN-1) Overexpression in Procyclic T. brucei
We sought to determine the effect of TbPARN-1 overexpression on global mRNA steady-state levels in T. brucei. The mRNA expression profile of tet-induced TbPARN-1 OvEx procyclic cells was compared to the mRNA profile of control cells (expressing tet-induced TAP tag alone) by microarray analysis. S...
ORGANISM(S): Trypanosoma brucei 
2010-03-04 | E-GEOD-20593 | biostudies-arrayexpress
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