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MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
ProteomicsHuman Lysozyme Treated Salmonella Tm. Supernatant
lysozyme-untreated Salmonella spent media and lysozyme-treated salmonella supernatant have different effects on intestinal epithelial permeability. To analyze the content and the different between the two supernatants, we did the proteomics to identify the proteins.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2024-08-10 | PXD049696 | Pride
Virulence proteins Salmonella tm. Supernatant Lysozyme 
TranscriptomicsStress response of Salmonella Typhimurium to acidified nitrite
The antimicrobial action of the curing agent NaNO2, which is added as a preservative to raw meat products, depends on its conversion to nitric oxide and other reactive nitrogen species under acidic conditions. In this study, we applied RNA-sequencing to analyze the acidified NaNO2 shock and adaptive...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2014-08-25 | E-GEOD-57238 | biostudies-arrayexpress
TranscriptomicsGlobal cellular adaptation to biocides and antibiotics in Salmonella enterica
The present project investigates transcriptomics changes in laboratory mutants of Salmonella typhimurium SL1344 obtained by pre-exposure to biocides, including triclosan (TRI), benzalkonium chloride (BZC), and chlorexidine (CHX), and antibiotics including Ampicillin (AP) and ciprofloxacin (Cip), as...
ORGANISM(S): Salmonella enterica serovar Dublin 
2016-06-30 | E-MTAB-2554 | biostudies-arrayexpress
TranscriptomicsSalmonella enterica serovar Typhimurium strain 14028s transcriptome response to tomato media
Summary: Salmonella enterica serovar Typhimurium strain 14028s transcriptome response to tomato medium (TM) and tomato root exudates (TX) compared to minimal medium (MM). Purpose: Salmonella mRNA profile, when grown in different media was compared to minimal medium to reveal environment specific tra...
ORGANISM(S): Salmonella enterica 
2020-03-31 | GSE132634 | GEO
ProteomicsSalmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection
Subversion of the host cytoskeleton is a critical virulence mechanism used by a variety of intracellular bacterial pathogens during their infectious life cycles. Growing evidence suggests that the tactics employed by pathogens are surprisingly diverse. Using proteomic and biochemical methods, we dem...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD028785 | Pride
Human Lc-ms Vimentin S.tm 
TranscriptomicsFibroblast transcription pattern in Salmonella infected Vs uninfected cells
Human fibroblasts were infected with GFP-expressing Salmonella enterica serovar Typmimurium and further separated by Fluorescence Activated Cell Sorting. RNA from infected and uninfected cells sub-populations were used for genome-wide expression studies 3 independent experiments enabled us to obtain...
ORGANISM(S): Homo sapiens 
2016-08-04 | E-GEOD-71727 | biostudies-arrayexpress
TranscriptomicsTraf6 function in the innate immune response of zebrafish embryos
Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. Two-way factorial dual colour design with factor 1 'infection with Salmonella ...
ORGANISM(S): Danio rerio 
2010-08-01 | E-GEOD-20310 | biostudies-arrayexpress
TranscriptomicsTraf6 function in the innate immune response of zebrafish embryos
Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. All infection experiments were performed using mixed egg clutches of ABxTL str...
ORGANISM(S): Danio rerio 
2010-08-01 | E-GEOD-21024 | biostudies-arrayexpress
GenomicsSalmonella enterica subsp. enterica
Salmonella enterica serovar Typhimurium 14028s Tn-seq library sequencing
PRJNA973854 | ENA
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