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UnknownConserved Mechanism of Conformational Stability and Dynamics in G-Protein-Coupled Receptors.
Not available
S-EPMC5148705 | biostudies-literature
UnknownIdentification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts.
Not available
S-EPMC2198976 | biostudies-literature
ProteomicsLck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell antigen receptor (TCR) signaling depends upon the kinases Lck and Zap70. Lck phosphorylates the TCR, facilitating Zap70 recruitment to the stimulated TCR. Lck also phosphorylates Zap70, relieving its auto-inhibition and activating its catalytic domain. Zap70 then phosphorylates the critical a...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008258 | Pride
Jurkat t cell line Lat Tcr signaling Mice Lck Zap70 
UnknownLocal and systemic immunomodulatory mechanisms triggered by Human Papillomavirus transformed cells: a potential role for G-CSF and neutrophils.
Not available
S-EPMC5566396 | biostudies-literature
TranscriptomicsDefining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation [RNA-Seq]
Memory T cells are primed for rapid responses to antigen; however, the molecular mechanisms responsible for priming remain incompletely defined. CpG methylation in promoters is an epigenetic modification, which regulates gene transcription. Using targeted bisulfite sequencing, we examined methylatio...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-59846 | biostudies-arrayexpress
UnknownMice transgenic for a human porcine endogenous retrovirus receptor are susceptible to productive viral infection.
Not available
S-EPMC1440412 | biostudies-literature
ProteomicsSILAC proteomics of cancer-associated fibroblasts (CAFs) and cancer cells
To study bi-directional signaling between cancer-associated fibroblasts (CAFs) and cancer cells, we used stable isotope labeling by amino acids in cell culture (SILAC) to determine changes in tyrosine phosphorylation upon direct contact of the two cell types.
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD003574 | Pride
Cancer-associated fibroblasts Cancer cells Silac 
UnknownPersistence of immunoglobulin G after natural infection with SARS‐CoV‐2
Not available
S-EPMC8128357 | biostudies-literature
ProteomicsDeep phosphotyrosine characterization of mouse primary T cells using Broad Spectrum Optimization of Selective Triggering
Sequencing the tyrosine phosphoproteome using MS-based proteomics is challenging due to the low abundance of tyrosine phosphorylation in cells, a challenge compounded in scarce samples like primary cells or clinical samples. The broad-spectrum optimization of selective triggering (BOOST) method was ...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD053863 | Pride
T cell Mus musculus Tmt 
ProteomicsVav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28 in CD3-stimulated T cells
Vav1, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T cell receptor (TCR) signaling cascade, is rapidly tyrosine phosphorylated in response to T cell activation. Previous studies using Vav1 knockout models have demonstrated its importance in TCR signaling. Although Vav...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD002022 | Pride
T cell receptor Tyrosine phosphorylaiton Vav1 
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