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TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clinical problem. The current study used a pre-clinical model of induction therapy for pediatric ALL in NOD/SCID mice (Samuels et al Blood Cancer Journal (2014) 4, e232; doi:10.1038/bcj.2014.52)...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-MTAB-4759 | biostudies-arrayexpress
TranscriptomicsA Pre-clinical model of induction therapy and relapse in pediatric acute lymphoblastic leukemia
The development of a clinically relevant xenograft model of pediatric acute lymphoblastic leukemia, using a 4-drug treatment regimen designed to mimic pediatric remission induction therapy. Relapse and acquired drug resistance in T-cell acute lymphoblastic leukemia (T-ALL) remains a significant clin...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-MEXP-3916 | biostudies-arrayexpress
ProteomicsImmunopeptidomic analyses - HLA Export by Melanoma Cells Decoys Cytotoxic T Cells to Promote Immune Evasion
While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by melanoma cells are decorated with MHC molecules that stimulate C...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-19 | PXD069094 | Pride
Melanoma Melanosomes Immunopeptidome 
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD025499 | Pride
Sars-cov-2 Immunopeptidomics Hla-peptidomics 
UnknownA cluster randomised effectiveness-implementation trial of an intervention to increase the adoption of PAX Good Behaviour Game, a mental health prevention program, in Australian primary schools: Study protocol.
Not available
S-EPMC9163694 | biostudies-literature
UnknownCompendium of proteins containing segments that exhibit zero-tolerance to amino acid variation in humans.
Not available
S-EPMC9387208 | biostudies-literature
UnknownCo-design and Development of Implementation Strategies: Enhancing the PAX Good Behaviour Game in Australian Schools.
Not available
S-EPMC10638156 | biostudies-literature
TranscriptomicsGlucocorticoid Resistance Gene Profiling in T-ALL Cell Lines
Baseline glucocorticoid resistance profiles were measured in a panel of 15 paediatric T-Cell acute lymphoblastic leukaemia cell lines and correlated with Affymetrix Gene expression to identify genes and pathways associated with drug resistance in T-ALL. The cell lines' resistance to Methylprednisolo...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-MTAB-1208 | biostudies-arrayexpress
UnknownAssociation of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study.
Not available
S-EPMC6528171 | biostudies-literature
UnknownA pre-clinical model of resistance to induction therapy in pediatric acute lymphoblastic leukemia.
Not available
S-EPMC4219466 | biostudies-literature
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