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ProteomicsTranslation dysregulation in cancer as a source for targetable antigens
Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized as foreign by T cells. Protein synthesis in malignant cells is dysregulated, resulting in the production of non-canonical aberrant peptides. We hypot...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-03-25 | PXD053256 | Pride
Human Mapp Cancer Proteome Mice Immunopeptidome 
ProteomicsImmunopeptidomic analyses - HLA Export by Melanoma Cells Decoys Cytotoxic T Cells to Promote Immune Evasion
While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by melanoma cells are decorated with MHC molecules that stimulate C...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-19 | PXD069094 | Pride
Melanoma Melanosomes Immunopeptidome 
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-01 | MSV000088298 | MassIVE
ProteomicsLarge-Scale Immuno-Peptidome Analysis Reveals Recurrent Post-Translational Splicing of Cancer and Immune-Associated Genes
Post translational spliced peptides bound to the HLA are unique type of peptides, shown in cancer, for HLA-class-I. Thus far, no consensus has been reached on the extent to which post-translational spliced peptides (PTSPs) occur, stirring significant debate. Furthermore, the role of the HLA-class-II...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-10 | PXD034788 | Pride
Human Lc-msms Melanoma 
ProteomicsImmunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma
Predicting the outcome of immunotherapy treatment in melanoma patients is challenging. Alterations in genes involved in antigen presentation and the interferon gamma (IFN) pathway play an important role in the immune response to tumors. We describe here that the overexpression of PSMB8 and PSMB9, tw...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD015957 | Pride
Immunoproteasome Neoantigens Melanoma Tumor associated antigens Hla peptidomics 
ProteomicsLymphodepleting chemotherapy potentiates neoantigen-directed T-cell therapy by enhancing antigen presentation
Adoptive cell therapy (ACT) targeting tumor-specific antigens holds promise for solid-tumors, but limited neoantigen presentation remains a key barrier to efficacy. Here, we identify and characterize a T-cell receptor (TCR), T104, for the KRAS.G12V mutation, a prevalent neoantigen in colorectal, lun...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD070607 | Pride
Kras g12v Lymphodepleting chemotherapy Proteomics Kras g12c Tcr therapy Neoantigens Colon cancer. Adoptive cell therapy Immunotheraphy Pancreatic cancer 
ProteomicsRecurrent immunogenic neoantigens and their cognate T-cell receptors in treatment-resistant metastatic prostate cancer
New approaches that generate long-lasting therapeutic responses in therapy-resistant metastatic cancer patients are urgently needed. To address this challenge, we developed SpotNeoMet, a novel data-driven pipeline that systematically identifies recurrently presented neopeptides in treatment-resistan...
ORGANISM(S): Homo sapiens (Human) 
2025-10-03 | PXD055544 | Pride
Treatment resistance T cell receptor Neopeptide 
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD025499 | Pride
Sars-cov-2 Immunopeptidomics Hla-peptidomics 
ProteomicsIdentification of microbial-derived HLA-bound peptides in melanoma
Various bacterial species are known to colonize human tumors , proliferate within them and modulate immune function, ultimately affecting patient survival and response to treatment. However, it is not known whether intracellular bacterial antigens are presented by HLA-I and HLA-II molecules of tumor...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD022150 | Pride
Human Lc-msms Hla peptidomics Microbiome Immunopeptidomics 
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