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TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve ad...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
TranscriptomicsEffect of Ribavirin on Viral Kinetics and Liver Gene Expression in Chronic Hepatitis C
Background/Aims: Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of response and mechanism of action of ribavirin in treatment of hepatitis C. Methods: 70 treatment-naïve patients were rand...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-38663 | biostudies-arrayexpress
ProteomicsProteomics after co-immunoprecipitation of myosin/MHC B/UNC-54 (with a Gly387Arg mutation) from C. elegans worms grown on nhl-1 or F40A3.6 RNAi compared to control RNAi
This project includes 20 samples after immunoprecipitation of C. elegans myosin heavy chain B (MHC B/UNC-54/F11C3.3, UniProt P02566 with a Gly387Arg mutation) in 4 replicates of 4 conditions. Lysates from a myosin-misfolding C. elegans strain (unc-54(e1301) with a Gly387Arg substitution in MHC B) gr...
ORGANISM(S): Caenorhabditis elegans 
2024-07-16 | PXD045076 | Pride
Myosin C. elegans Co-immunoprecipitation Rnai Interactome Muscle 
UnknownPdII-Catalyzed Oxidative Aldehyde-sp2C-H Functionalization and Cyclization Using NHC with Mild Oxidant DMSO for the Selective Synthesis of Esters, Sugar-Based Analogues, and β-Hydroxy Chromanones: An 18O-Labeling Study.
Not available
S-EPMC6044719 | biostudies-literature
UnknownIntramolecular C-H Oxidation in Iron(V)-oxo-carboxylato Species Relevant in the γ-Lactonization of Alkyl Carboxylic Acids.
Not available
S-EPMC11420956 | biostudies-literature
ProteomicsTMT-based quantitative proteomics to compare the proteomes of wild-type and unc-45(m94) animals during the recovery phase in C. elegans
The wild-type (WT) and unc-45(m94) C. elegans were cultured at 15 °C under normal conditions and shifted to 25 °C for 16–18 h at the L4 stage, followed by recovery at 15 °C. In WT animals, muscle integrity and protein homeostasis are efficiently restored during recovery, whereas in unc-45(m94) mutan...
ORGANISM(S): Caenorhabditis elegans 
2026-10-26 | PXD069277 | Pride
Mutant unc-45(m94) Muscle-specific chaperone unc-45 C.elegans 
ProteomicsWhole worm proteomics after optogenetically induced mechanical muscle stress (OptIMMuS)
This project includes 16 samples of transgenic C. elegans whole worm lysate after mechanical stress in 4 replicates of 4 conditions. Transgenic C. elegans strains expressing the optogenetic channelrhodopsin mutant ChR2(C128S;H134R)-FLAG in body wall muscle cells (PP3189 hhIs251[myo-3p::ChR2(C128S,H1...
ORGANISM(S): Caenorhabditis elegans 
2024-07-16 | PXD045078 | Pride
C. elegans Optogenetics Mechanical stress Muscle 
ProteomicsTMT-based quantitative proteomics to compare the proteomes of wild-type and allo-1 overexpression animals in C. elegans
Wild-type and allo-1 overexpression (OE) animals were cultured at 20 °C under standard conditions. This TMT-based quantitative proteomics dataset identifies proteins that are differentially regulated in allo-1 OE animals compared to wild type.
ORGANISM(S): Caenorhabditis elegans 
2026-10-26 | PXD069274 | Pride
Allo-1 Overexpression Whole body protein extract C.elegans 
ProteomicsApolipoprotein A-II Increases Cholesterol Efflux Capacity of Mature High-Density Lipoproteins Via the Apolipoprotein A-I C-terminus
Samples were processed using Global and Limited Proteolysis (LiP). Peptides and proteins were identified using MaxQuant (v1.6.17.0), then summarized using R package RomicsProcessor.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-29 | MSV000095479 | MassIVE
UnknownFatigue before, during and after antiviral therapy of chronic hepatitis C: results from the Virahep-C study.
Not available
S-EPMC3477271 | biostudies-literature
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