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TranscriptomicsCircadian gene expression from wild type MEFs
Expression profiles in WT MEF at different circadian time point after dexamethasone synchronization. We used the Affymetrix expression microarrays to detail the circadian gene expression from wild type mouse embryonic fibroblasts during a 24 hour circadian cycle. For each circadian time point (CT), ...
ORGANISM(S): Mus musculus 
2013-08-08 | E-GEOD-49638 | biostudies-arrayexpress
TranscriptomicsSIRT6 and SIRT1 contribute to circadian gene expression
Comparison of the hepatic circadian transcriptomes reveals that SIRT6 and SIRT1 separately control transcriptional specificity, and therefore, define distinctly partitioned classes of circadian genes. Livers from WT and SIRT6 KO mice, and livers from WT and SIRT1 KO mice, were harvested over the cir...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-57830 | biostudies-arrayexpress
ProteomicsBMAL1 associates with NOP58 in the nucleolus and contributes to pre-rRNA processing
The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II. By using biochemical cellular fractionation and immunofluorescence analyses we reveal a previously uncharacterized nucleolar localization for BMAL1. W...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-25 | PXD018946 | Pride
Bmal1 interactome Nucleolus Circadian clock Ribosome biogenesis 
TranscriptomicsCycles in spatial and temporal chromosomal organization driven by the circadian clock
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-08-08 | E-GEOD-49639 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma distally rewires hepatic circadian homeostasis
Gene expression was performed in WT and tumor-bearing (TB) mice to determine the effects of a lung tumor on circadian clock of the liver. Livers from WT and TB (KrasLSL-G12D;p53fl/fl) mice were harvested over the circadian cycle at ZT 0, 4, 8, 12, 16 and 20 for gene expression analysis.
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-73222 | biostudies-arrayexpress
TranscriptomicsIdentification of MVH target mRNA
During mammalian spermatogenesis the mouse VASA homolog (MVH), a germ cell-specific DEAD-box type RNA binding protein, localizes in a germline-specific RNA granule termed the chromatoid body (CB). Genetic analyses have revealed that MVH is essential to progress through spermatogenesis, although the ...
ORGANISM(S): Mus musculus 
2011-08-30 | E-GEOD-30144 | biostudies-arrayexpress
TranscriptomicsChromosome conformation capture-on-chip of dexamethasone synchronized cells at several circadian times
The spatial organization of genes in the interphase nucleus plays an important role in establishment and regulation of gene expression. The circadian expressed and clock controlled genes represent about 10% of the transcripts in the mammalian cells, however the role of genome topology in the express...
ORGANISM(S): Mus musculus 
2013-08-08 | E-GEOD-49582 | biostudies-arrayexpress
TranscriptomicsExpression data from white and brown adipose tissue (WAT and BAT) of per2-/- and control mice
We found that the circadian protein PER2 interacts with the nuclear receptor PPARgamma to repress its activity. PPARgamma is a master regulator of adipogenesis and lipid metabolism and is very abundant in adipose tissue. We used microarrays to detail the global program of gene expression in adipose ...
ORGANISM(S): Mus musculus 
2010-10-19 | E-GEOD-20165 | biostudies-arrayexpress
TranscriptomicsCircadian adaptive signaling to critical ROS stress for cell survival
Disruption of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how nearly lethal stresses affect circadian clocks. We found that near-lethal doses of reactive oxygen species (ROS)-induced critical oxidative stress (cOS) at the branch poin...
ORGANISM(S): Mus musculus 
2013-11-09 | E-GEOD-47955 | biostudies-arrayexpress
TranscriptomicsCircadian transcriptome of fast tibialis anterior (TA) and slow soleus (SOL) skeletal muscles from muscle-specific Bmal1 KO and control Cre- littermates
To investigate the role of the circadian clock gene Bmal1 in skeletal muscle, we compared the circadian transcriptomes of fast tibialis anterior (TA) and slow soleus (SOL) skeletal muscles from muscle-specific Bmal1 KO (mKO) and their control Cre- littermates (Ctrl). Keyword: Circadian Transcriptome...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-43071 | biostudies-arrayexpress
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