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GenomicsImmune challenged SC-islets first response profiled by single cell transcription analysis after co-culture with human allogeneic PBMCs [scRNA-seq_invitro]
Immune challenged SC-islets first response profiled by single cell transcription analysis after co-culture with human allogeneic PBMCs [scRNA-seq_invitro]
PRJNA822846 | ENA
ProteomicsHuman pancreas and SC-beta phosphoproteomics
Using quantitative phosphoproteomic analysis of human islets and human stem-cell-derived islets (SC-islets), we show that mTORC1 inhibition with Torin-1 or rapamycin induces significant alterations in the phosphorylation profile of human islet cells.
ORGANISM(S): Homo sapiens (Human) 
2025-05-12 | PXD062389 | Pride
Human Pancreas Sc-beta Phosphoproteomics Mtor 
TranscriptomicsImmune challenged SC-islets first response profiled by single cell transcription analysis after co-culture with human allogeneic PBMCs [scRNA-seq_invitro]
We performed an in vitro co-culture of allogeneic PBMCs and SC-islet clusters. SC-islet clusters were enriched for β cells (using CD49A magnetic sorting; SC-α still remain at lower numbers) (Veres et al., 2019), dissociated and reaggregated to obtain a more uniform cell count between wells. SC-islet...
ORGANISM(S): Homo sapiens 
2022-09-01 | GSE200084 | GEO
GenomicsImproving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet snRNA-seq]
Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet snRNA-seq]
PRJNA836325 | ENA
GenomicsImproving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]
Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet_snATAC]
PRJNA836326 | ENA
GenomicsImproving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet scRNA-seq]
Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes [SC-islet scRNA-seq]
PRJNA836327 | ENA
ProteomicsEDC exposure during SC-islet differentiation
We aimed to asses how EDC exposure in combination with a genetic predisposition for diabetes could impact pancreatic endocrine cell development. For this, we used a protocol to generate Stem-cell islets (SC-islets) from induced pluripotent stem cells (iPSCs) following a 7 satege protocol. For 2 week...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD065436 | Pride
Sc-islets Ipscs Edc 
TranscriptomicsSingle nuclei multiomics of human stem cell-derived islets identifies deficiencies in lineage specification
We profiled the transcritpome and ATAC profiles of human pancreatic islets generated from pluripotent stem cells. Multiomic profiling was also performed on primary human islets and in vivo matured SC-islets for comparision. We catalogued the ATAC associated signatures for each cell types in SC-islet...
ORGANISM(S): Homo sapiens 
2023-03-25 | GSE199636 | GEO
TranscriptomicsAn optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines
Future success of cell therapy for type 1 diabetes (T1D) relies on robust protocols for the differentiation of stem cells to pancreatic islets. However, currently established protocols generate stem cell-derived pancreatic islets (SC-islets) which contain non-endocrine cell populations and have imma...
ORGANISM(S): Homo sapiens 
2026-03-27 | GSE270864 | GEO
TranscriptomicsImprove cellular fitness of human stem cell-derived islets under hypoxia
Stem cell-derived islet (SC-islet) cell therapy holds immense potential for the treatment of Type 1 Diabetes. However, low oxygen supply leads to cell dysfunction post-transplantation, especially in subcutaneous spaces and encapsulation devices. The response of SC-islets to hypoxia and effective str...
ORGANISM(S): Homo sapiens 
2025-03-24 | GSE263130 | GEO
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