Sort   by:  
 Page size 
ProteomicsLC-MS/MS of SCA3 knock-in mouse cortex, cerebellum, and axons
Spinocerebellar ataxia type 3 (SCA3/MJD) has a polyQ etiology but, the current knowledge on molecular processes and proteins involved in pathogenesis is insufficient. Due to its proteolytic function, Ataxin-3 can influence other proteins, yet the global picture of crucial proteins and pathways in SC...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-08 | PXD024945 | Pride
Ataxin-3 Brain Cerebellum Cag Axon Mjd Mouse Sca3 Cerebral cortex Lc-ms/ms Knock-in Knockin Spinocerebellar Ataxia Polyq Neurodegenerative Proteome 
GenomicsTranscriptional changes in mouse models in SCA3
Transcriptional changes in mouse models in SCA3
PRJNA482631 | ENA
TranscriptomicsTranscription profiling of mouse spinocerebellar ataxia type 3 (SCA3) transgenic and wild type animals treated with CCI-779 or placebo
Spinocerebellar ataxia type 3 is a neurodegenerative disorder caused by the expansion of the polyglutamine repeat region within the ataxin-3 protein. The mutant protein forms intracellular aggregates in the brain. However, the cellular mechanisms causing toxicity are still poorly understood and ther...
ORGANISM(S): Mus musculus 
2009-09-18 | E-GEOD-17994 | biostudies-arrayexpress
GenomicsTranscriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms
Transcriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms
PRJNA1336220 | ENA
GenomicsTranscriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [Human_RNAseq]
Transcriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [Human_RNAseq]
PRJNA1336241 | ENA
GenomicsTranscriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [KO_RNAseq]
Transcriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [KO_RNAseq]
PRJNA1336244 | ENA
TranscriptomicsExpression data from SCA3 and genetically corrected iPSCs
The neurodegenerative disease spinocerebellar ataxia type 3 (SCA3; also called Machado-Joseph disease, MJD) is a trinucleotide repeat disorder caused by expansion of CAG repeats which encoding an abnormal long polyglutamine (polyQ) tract in ataxin-3 of the ATXN3 gene. Even now the pathogenic mechani...
ORGANISM(S): Homo sapiens 
2020-01-17 | GSE93713 | GEO
TranscriptomicsTranscriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by polyglutamine repeat expansion in the ATXN3 gene. Despite the ubiquitous expression of ATXN3 throughout the body, SCA3 pathology is pronounced in select, vulnerable regions within the central nervous system (CNS). Notably,...
ORGANISM(S): Mus musculus 
2025-10-29 | GSE309535 | GEO
GenomicsMultimodal characterization of sensorimotor peripheral neuropathy in a preclinical mouse model of SCA3
Multimodal characterization of sensorimotor peripheral neuropathy in a preclinical mouse model of SCA3
PRJNA1426384 | ENA
TranscriptomicsTranscriptional dysregulation in the spinal cord of SCA3 provides insights into disease mechanisms [KO_RNAseq]
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disease caused by polyglutamine repeat expansion in the ATXN3 gene. Despite the ubiquitous expression of ATXN3 throughout the body, SCA3 pathology is pronounced in select, vulnerable regions within the central nervous system (CNS). Notably,...
ORGANISM(S): Mus musculus 
2025-10-29 | GSE309549 | GEO
Sort   by:  
 Page size